乳腺癌是全世界女性发病和死亡的主要原因。本研究旨在评估 1990 年至 2021 年间 204 个国家和地区的乳腺癌全球负担，并确定可归因的危险因素。利用 2021 年全球疾病负担研究的数据，我们分析了发病率、死亡率、伤残调整生命年（ DALY）以及与乳腺癌相关的危险因素。我们获取并分析了 1990 年至 2021 年的年龄标准化发病率 (ASIR)、年龄标准化死亡率 (ASDR) 和年龄标准化 DALY 率。我们评估了地理变化和社会人口指数 (SDI) 的影响使用回归分析和 SDI 五分位数分层。此外，我们使用 GBD 研究的比较风险评估框架估计了乳腺癌死亡和 DALY 的风险因素。全球范围内，乳腺癌发病病例从 1990 年的 875,657 例增加到 2021 年的 2,121,564 例。ASIR 从每 10 万人中 16.42 上升到 26.88 例（95% CI：1.54-1.60）。高 SDI 区域的 ASIR 最高（2021 年为每 100,000 人 66.89），而低 SDI 区域的 ASIR 最低（2021 年为每 100,000 人 6.99）。 1990 年至 2021 年间，全球 ASDR 从每 10 万人 10.42 下降至 8.54，年龄标准化 DALY 率从每 10 万人 313.36 下降至 261.5。然而，这些改善在各个 SDI 地区并不统一。危险因素包括高体重指数、饮酒、吸烟和高空腹血糖，不同 SDI 区域存在差异。从 1990 年到 2021 年，全球乳腺癌负担显着增加，不同 SDI 区域存在差异。虽然高 SDI 地区的死亡率和伤残调整生命年 (DALY) 有所改善，但低 SDI 地区却面临着日益增加的负担。针对可改变的风险因素和改善欠发达地区的医疗保健可及性的有针对性的干预措施对于减少乳腺癌的全球影响至关重要。© 2024。作者。

Breast cancer is a leading cause of morbidity and mortality among women worldwide. This study aimed to assess the global burden of breast cancer and identify attributable risk factors across 204 countries and territories from 1990 to 2021.Using data from the Global Burden of Disease Study 2021, we analyzed the incidence, mortality, disability-adjusted life years (DALYs), and risk factors associated with breast cancer. We obtained and analyzed the age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and age-standardized DALYs rate from 1990 to 2021. We assessed geographical variations and the impact of the Socio-demographic Index (SDI) using regression analysis and stratification by SDI quintiles. Additionally, we estimated the risk factors attributable to breast cancer deaths and DALYs using the comparative risk assessment framework of the GBD study.Globally, breast cancer incident cases increased from 875,657 in 1990 to 2,121,564 in 2021. The ASIR rose from 16.42 to 26.88 per 100,000 (95% CI: 1.54-1.60). High SDI regions showed the highest ASIR (66.89 per 100,000 in 2021), while Low SDI regions had the lowest (6.99 per 100,000 in 2021). The global ASDR decreased from 10.42 to 8.54 per 100,000, and the age-standardized DALYs rate decreased from 313.36 to 261.5 per 100,000 between 1990 and 2021. However, these improvements were not uniform across SDI regions. Risk factors included high body-mass index, alcohol use, tobacco, and high fasting plasma glucose, with variations across SDI regions.The global burden of breast cancer has increased significantly from 1990 to 2021, with disparities observed across SDI regions. While high SDI areas show improvements in mortality and DALYs, lower SDI regions face increasing burdens. Targeted interventions addressing modifiable risk factors and improving healthcare access in less developed regions are crucial for reducing the global impact of breast cancer.© 2024. The Author(s).