定期体育锻炼对于预防癌症、减少疲劳、治疗副作用和复发、提高癌症患者的生活质量和总体生存率的好处越来越受到人们的认可。初步研究表明，体力活动期间细胞外囊泡 (EV) 的浓度会增加，并且 EV 携带生物活性物质。这些 EV 由血细胞、骨骼肌和其他参与运动的器官释放，因此表明 EV 可能介导运动期间的组织串扰。这种可能性引发了人们对研究 EV 在系统性运动适应中的作用及其在预防和治疗包括癌症在内的各种疾病中的潜在应用的极大兴趣。本综述介绍了探索运动期间释放的 EV 浓度和分子货物的研究。此外，我们还讨论了可能触发各种细胞类型释放 EV 的假定刺激、运动诱导的 EV 的生物学功能以及对癌症发生和进展的影响。了解运动、EV 和癌症生物学之间的相互作用可能会为癌症的新颖治疗策略和预防措施提供见解。© 2024 作者。 《Journal of Extracellular Vesicles》由 Wiley periodicals LLC 代表国际细胞外囊泡学会出版。

The benefits of regular physical exercise on cancer prevention, as well as reducing fatigue, treatment side effects and recurrence, and improving quality of life and overall survival of cancer patients, are increasingly recognised. Initial studies showed that the concentration of extracellular vesicles (EVs) increases during physical activity and that EVs carry biologically active cargo. These EVs are released by blood cells, skeletal muscle and other organs involved in exercise, thus suggesting that EVs may mediate tissue crosstalk during exercise. This possibility triggered a great interest in the study of the roles of EVs in systemic adaptation to exercise and in their potential applications in the prevention and treatment of various diseases, including cancer. This review presents studies exploring the concentration and molecular cargo of EVs released during exercise. Furthermore, we discuss putative stimuli that may trigger EV release from various cell types, the biological functions and the impact of exercise-induced EVs on cancer development and progression. Understanding the interplay between exercise, EVs, and cancer biology may offer insights into novel therapeutic strategies and preventive measures for cancer.© 2024 The Author(s). Journal of Extracellular Vesicles published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.