中国惠州人类乳头瘤病毒感染的流行病学和基因型分析
Epidemiology and genotypes analysis of human papillomavirus infection in Huizhou, China
影响因子:3.40000
分区:医学3区 / 公共卫生3区
发表日期:2024
作者:
Zhun Shu, Wenli Zhao, Xuebing Zhan, Jiaqi Zeng, Jingyi Li
摘要
人乳头瘤病毒（HPV）是宫颈癌的主要致病因素。 HPV的患病率和基因型分布在不同区域有所不同。因此，我们的研究旨在研究中国惠州HPV的流行病学。在5,325名女性门诊患者中检测到HPV测试，我们专注于HPV的总体HPV患病率，基因型分布和HPV基因型与宫颈certology的相关性。 HPV39，HPV16和HPV51是单一感染率为70.80％的主要基因型。 HPV感染率显示出U形年龄分布，在5个年龄组之间观察到统计差异（χ2= 50.497，p <0.01），并且较高的正率在30（34.42％）和60岁以上（34.74％）的年龄较高（34.42％）下。在高危HPV（HRHPV）感染中，有60.69％的尼尔姆（NILM）为0.99％HSIL。多种HRHPV感染中的宫颈病变程度比单一感染中的宫颈病变差（p <0.01）。hPV感染率在Huizhou，Guangdong，单一感染中很高。 HPV感染带有U形年龄分布。多种HRHPV感染令人担忧，因为它可能会加剧宫颈病变。妇女应更加关注HPV检测，并根据当地的HPV类型分布选择更合适的HPV疫苗。
Abstract
Human papillomavirus (HPV) is a main pathogenic factor for cervical carcinoma. The prevalence and genotypes distribution of HPV vary in different regions. Thus, our study aimed to investigate the epidemiology of HPV in Huizhou, China.HPV tests were detected in 5,325 female outpatients, we focused on the overall HPV prevalence, genotypes distribution, and the correlation of HPV genotypes with cervical cytology.The overall HPV prevalence was 27.53%, HPV52, HPV58, HPV39, HPV16 and HPV51 were predominant genotypes with single infection rate of 70.80%. HPV infection rate showed a U-shaped age distribution, statistical differences were observed among 5 age groups (χ2 = 50.497, p < 0.01), and the higher positive rate was aged under 30 (34.42%) and above 60 (34.74%). Among high-risk HPV (hrHPV) infections, 60.69% involved NILM, 0.99% HSIL. The degrees of cervical lesions in multiple hrHPV infections were worse than those in single infection (p < 0.01).The HPV infection rate is high in Huizhou, Guangdong, single infection was predominant. HPV infection presented with a U-shaped age distribution. Multiple hrHPV infection was worrying since it may aggravate cervical lesions. Women should pay more attention to HPV detection and choose a more appropriate HPV vaccine according to local HPV type distribution.