人乳头瘤病毒（HPV）是宫颈癌的主要致病因素。不同地区HPV的患病率和基因型分布存在差异。因此，我们的研究旨在调查中国惠州地区HPV的流行病学。对5,325名女性门诊患者进行HPV检测，重点关注HPV总体患病率、基因型分布以及HPV基因型与宫颈细胞学的相关性。总体HPV患病率HPV52、HPV58、HPV39、HPV16、HPV51为优势基因型，单次感染率为27.53%，单次感染率为70.80%。 HPV感染率呈U型年龄分布，5个年龄组间差异有统计学意义（χ2 = 50.497，p < 0.01），其中30岁以下（34.42%）和60岁以上（34.74%）阳性率较高。在高危型HPV（hrHPV）感染中，60.69%涉及NILM，0.99%涉及HSIL。多次hrHPV感染的宫颈病变程度较单一感染更严重(p<0.01)。广东惠州地区HPV感染率较高,以单一感染为主。 HPV感染呈U型年龄分布。多重hrHPV感染令人担忧，因为它可能会加重宫颈病变。女性应更加重视HPV检测，根据当地HPV型别分布选择更合适的HPV疫苗。版权所有©2024 Shu、Zhao、Zhan、Zeng、Li。

Human papillomavirus (HPV) is a main pathogenic factor for cervical carcinoma. The prevalence and genotypes distribution of HPV vary in different regions. Thus, our study aimed to investigate the epidemiology of HPV in Huizhou, China.HPV tests were detected in 5,325 female outpatients, we focused on the overall HPV prevalence, genotypes distribution, and the correlation of HPV genotypes with cervical cytology.The overall HPV prevalence was 27.53%, HPV52, HPV58, HPV39, HPV16 and HPV51 were predominant genotypes with single infection rate of 70.80%. HPV infection rate showed a U-shaped age distribution, statistical differences were observed among 5 age groups (χ2 = 50.497, p < 0.01), and the higher positive rate was aged under 30 (34.42%) and above 60 (34.74%). Among high-risk HPV (hrHPV) infections, 60.69% involved NILM, 0.99% HSIL. The degrees of cervical lesions in multiple hrHPV infections were worse than those in single infection (p < 0.01).The HPV infection rate is high in Huizhou, Guangdong, single infection was predominant. HPV infection presented with a U-shaped age distribution. Multiple hrHPV infection was worrying since it may aggravate cervical lesions. Women should pay more attention to HPV detection and choose a more appropriate HPV vaccine according to local HPV type distribution.Copyright © 2024 Shu, Zhao, Zhan, Zeng and Li.