中国惠州人乳头瘤病毒感染的流行病学与基因型分析

Epidemiology and genotypes analysis of human papillomavirus infection in Huizhou, China

DOI 原文链接

用sci-hub下载

FRONTIERS IN PUBLIC HEALTH

影响因子:3.4

分区:医学3区 / 公共卫生3区

发表日期:2024

作者: Zhun Shu, Wenli Zhao, Xuebing Zhan, Jiaqi Zeng, Jingyi Li

DOI: 10.3389/fpubh.2024.1440480

摘要

人乳头瘤病毒（HPV）是宫颈癌的主要病因之一。不同地区的HPV感染率及基因型分布存在差异。本研究旨在调查中国惠州地区HPV的流行病学情况。对5325名女性门诊患者进行了HPV检测，重点分析整体感染率、基因型分布及HPV基因型与宫颈细胞学变化的关系。结果显示，惠州地区HPV总感染率为27.53%，HPV52、HPV58、HPV39、HPV16和HPV51为主要感染基因型，单一感染比例为70.80%。HPV感染呈U形年龄分布，年龄组差异显著（χ2=50.497，p<0.01），30岁以下（34.42%）和60岁以上（34.74%）的阳性率较高。在高危型HPV（hrHPV）感染中，60.69%伴随宫颈阴性细胞学结果（NILM），0.99%伴随高级别病变（HSIL）。多重高危HPV感染的宫颈病变程度比单一感染更严重（p<0.01）。惠州地区HPV感染率较高，以单一感染为主。HPV感染呈U形年龄分布，多重高危型感染令人担忧，可能加重宫颈病变。建议女性加强HPV检测，并根据本地HPV型别分布选择更合适的疫苗。

Abstract

Human papillomavirus (HPV) is a main pathogenic factor for cervical carcinoma. The prevalence and genotypes distribution of HPV vary in different regions. Thus, our study aimed to investigate the epidemiology of HPV in Huizhou, China.HPV tests were detected in 5,325 female outpatients, we focused on the overall HPV prevalence, genotypes distribution, and the correlation of HPV genotypes with cervical cytology.The overall HPV prevalence was 27.53%, HPV52, HPV58, HPV39, HPV16 and HPV51 were predominant genotypes with single infection rate of 70.80%. HPV infection rate showed a U-shaped age distribution, statistical differences were observed among 5 age groups (χ2 = 50.497, p < 0.01), and the higher positive rate was aged under 30 (34.42%) and above 60 (34.74%). Among high-risk HPV (hrHPV) infections, 60.69% involved NILM, 0.99% HSIL. The degrees of cervical lesions in multiple hrHPV infections were worse than those in single infection (p < 0.01).The HPV infection rate is high in Huizhou, Guangdong, single infection was predominant. HPV infection presented with a U-shaped age distribution. Multiple hrHPV infection was worrying since it may aggravate cervical lesions. Women should pay more attention to HPV detection and choose a more appropriate HPV vaccine according to local HPV type distribution.