芳香酶抑制剂 (AI) 引起的肌肉骨骼症状 (AIMSS) 会降低与健康相关的生活质量，并导致患有乳腺癌 (BC) 的绝经后妇女停止接受 AI 治疗。尽管中枢敏化（CS）可能有助于 AIMSS，但 CS 相关症状与 AIMSS 的相关性尚未完全阐明。本研究旨在调查接受 AI 治疗的 BC 女性患者中 AIMSS 与 CS 相关症状之间的关系。这项横断面研究招募了至少 1 年前接受过 BC 手术且接受 AI 至少 6 个月的女性。使用中枢敏化量表 (CSI) 评估参与者的关节疼痛和 CS 相关症状。 CS相关症状的严重程度分为三组，并计算AIMSS的患病率。使用多元逻辑回归分析来评估 AIMSS 与可能与 AIMSS 相关的因素（包括 CSI 严重程度）之间的关系。 在本研究纳入的 73 名女性中，31 名 (42.4%) 被分类为 AIMSS 组，42 名 (57.6%) 被分类为 AIMSS 组。 %) 进入非 AIMSS 组。有化疗史和 CSI 评分较高的参与者患 AIMSS 的可能性明显更高。多元逻辑回归分析显示，化疗史（比值比 = 4.21）和较高的 CSI 严重程度（比值比 = 13.43）与 AIMSS 显着相关。使用 CSI 评估的 CS 相关症状可能与 AIMSS 密切相关。需要进一步纵向研究来调查 CS 针对性干预措施的因果关系和有效性，以有效预防和治疗 AIMSS。© 2024 S. Karger AG，巴塞尔。

Aromatase inhibitor (AI)-induced musculoskeletal symptoms (AIMSS) can decrease health-related quality of life and lead to discontinuation of AI therapy for postmenopausal women with breast cancer (BC). Although central sensitization (CS) may contribute to AIMSS, the relevance of CS-related symptoms to AIMSS has not been fully clarified. This study aimed to investigate the relationship between AIMSS and CS-related symptoms in women with BC who received AI therapy.This cross-sectional study recruited women who underwent BC surgery before at least 1 year and were taking AI for at least 6 months. Participants were assessed for joint pain and CS-related symptoms using the central sensitization inventory (CSI). The severity of CS-related symptoms was classified into three groups, and the prevalence of AIMSS was calculated. Multiple logistic regression analysis was used to assess the relationship between AIMSS and factors of possible relevance to AIMSS, including CSI severity.Of the 73 women who were included in this study, 31 (42.4%) were categorized into the AIMSS group and 42 (57.6%) into the non-AIMSS group. Participants with a history of chemotherapy and higher CSI score were significantly more likely to have AIMSS. Multiple logistic regression analysis showed that a history of chemotherapy (odds ratio = 4.21) and higher CSI severity (odds ratio = 13.43) had significantly associated with AIMSS.CS-related symptoms assessed using CSI may be strongly associated with AIMSS. Further longitudinal studies to investigate the causal relationship and effectiveness of CS-targeted interventions are needed to prevent and treat AIMSS effectively.© 2024 S. Karger AG, Basel.