微波热疗（MWTT）作为肿瘤的治疗方法，缺乏特异性并且需要敏化剂。大多数报道的微波敏化剂都是单一金属有机框架（MOF），必须负载离子液体才能增强 MWTT 的性能。同时，MWTT很少与其他治疗方式结合使用。在这里，我们通过水热法合成了一种新型的Fe-Cu双金属有机骨架FeCuMOF（FCM），并用甲基聚乙二醇（mPEG）对其进行了进一步修饰。所得FCM@PEG（FCMP）在低功率微波照射下表现出优异的加热性能；它还作为一种新型纳米球酶来催化 H2O2 分解，产生丰富的活性氧 (ROS) 以消耗谷胱甘肽 (GSH)，并在化学动力学治疗过程中防止肿瘤细胞清除 ROS。 FCMP 可生物降解，并表现出优异的生物相容性，使其易于代谢而不会引起毒性作用。最后，它被证明可以作为体外和体内 T2 磁共振成像 (MRI) 的合适试剂。这种新型双金属纳米结构可以成功实现两种肿瘤治疗方式（MWTT和化学动力学治疗）和双成像模式（T2 MRI和微波热成像）。我们的研究结果代表了肿瘤诊断和治疗一体化的突破，并为开发新型微波增敏剂提供了参考。© 2024 由 Elsevier B.V. 代表西安交通大学出版。

Microwave thermotherapy (MWTT), as a treatment for tumors, lacks specificity and requires sensitizers. Most reported microwave sensitizers are single metal-organic frameworks (MOFs), which must be loaded with ionic liquids to enhance the performance in MWTT. Meanwhile, MWTT is rarely combined with other treatment modalities. Here, we synthesized a novel Fe-Cu bimetallic organic framework FeCuMOF (FCM) by applying a hydrothermal method and further modified it with methyl polyethylene glycol (mPEG). The obtained FCM@PEG (FCMP) showed remarkable heating performance under low-power microwave irradiation; it also acted as a novel nanospheres enzyme to catalyze H2O2 decomposition, producing abundant reactive oxygen species (ROS) to deplete glutathione (GSH) and prevent ROS clearance from tumor cells during chemodynamic treatment. The FCMP was biodegradable and demonstrated excellent biocompatibility, allowing it to be readily metabolized without causing toxic effects. Finally, it was shown to act as a suitable agent for T2 magnetic resonance imaging (MRI) in vitro and in vivo. This new bimetallic nanostructure could successfully realize two tumor treatment modalities (MWTT and chemodynamic therapy) and dual imaging modes (T2 MRI and microwave thermal imaging). Our findings represent a breakthrough for integrating the diagnosis and treatment of tumors and provides a reference for developing new microwave sensitizers.© 2024 Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.