化学动力学疗法（CDT）面临着催化离子效率低和ROS产生低的挑战。为了解决这些问题，我们开发了一种ROS纳米炸弹Cu/ZIF-8@GA-Fe。该纳米炸弹是通过将铜掺杂到ZIF-8中并组装Fe3和没食子酸（GA）来合成的。测试了酸性条件下活性氧（ROS）的产生及其光热性能。在酸性微环境中，Cu/ZIF-8@GA-Fe有效释放Fe3和Cu2，消耗GSH并产生ROS。 GA-Fe 涂层提供光热，并用于通过双离子增强 Fenton 反应，以增加 ROS 产量。在体内和体外实验中，Cu/ZIF-8@GA-Fe 抑制肿瘤生长，且副作用极小。Cu/ZIF-8@GA-Fe 显示了安全有效的 CDT 的前景，为肿瘤治疗提供了一种协同方法。© 2024 孔等人。

Chemodynamic therapy (CDT) faces challenges of low catalytic ion efficiency and ROS production. We developed a ROS nano-bomb, Cu/ZIF-8@GA-Fe, to address these issues.The nano-bomb was synthesized by doping copper into ZIF-8 and assembling Fe3+ and gallic acid (GA). It was tested for reactive oxygen species (ROS) generation in acidic conditions and its photothermal properties.In an acidic micro environment, Cu/ZIF-8@GA-Fe effectively released Fe3+ and Cu2+, depleting GSH and generating ROS. The GA-Fe coating provided photothermal heat and was used to enhance Fenton reactions via dual ions for increasing ROS production. In vivo and in vitro experiments, Cu/ZIF-8@GA-Fe inhibited tumor growth with minimal side effects.Cu/ZIF-8@GA-Fe shows promise for safe and effective CDT, offering a synergistic approach to tumor therapy.© 2024 Kong et al.