各种试验已证明乐伐替尼加派姆单抗对晚期或复发性子宫内膜癌患者的临床益处，无论错配修复（MMR）状态或组织学亚型如何。之前发表的大多数试验样本量都很小。在这里，我们的目的是评估已报道的乐伐替尼加派姆单抗治疗晚期和复发性子宫内膜癌患者的疗效和安全性。我们利用 Cochrane Library、PubMed、Web of Science 和 Embase 数据库来确定评估乐伐替尼疗效和安全性的临床试验加派姆单抗治疗晚期和复发性子宫内膜癌患者。分析的结果包括无进展生存期（PFS）、总生存期（OS）、客观缓解率（ORR）、疾病控制率（DCR）和不良事件（AE）发生率。根据 MMR 状态（缺陷、dMMR 或良好、pMMR）进行亚组分析。纳入了四项试验（582 名患者）。汇总 ORR 为 32.7% [95% 置信区间 (CI)：28.9-36.5]。亚组分析显示，dMMR 组的 ORR 为 48.1%（95% CI：26.1-70.2），pMMR 组的 ORR 为 33.1%（95% CI：25.7-40.6）。合并后的 DCR 为 74.9%（95% CI：71.3-78.4%）。亚组分析显示 dMMR 组的 DCR 为 81.0%（95% CI：64.5-97.6），pMMR 组的 DCR 为 76.3%（95% CI：66.3-86.3）。所有纳入的研究均报告了随访情况。 PFS 和 OS 的中位时间范围分别为 5.3 个月至 258 天和 17.2 个月（未达到）。关于安全性，任何级别 AE 和 ≥ 3 级 AE 的总体汇总比例分别为 95.8% (95% CI: 89.5-100.0) 和 80.2% (95% CI: 59.9-100.0)。 乐伐替尼联合派姆单抗显示出相关的安全性对晚期和复发性子宫内膜癌患者具有临床益处和显着毒性。需要进行涉及长期结果的进一步研究。https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=522160/，标识符 CRD42024522160。版权所有 © 2024 Yan、Du、Zhang、Yan、Liu 、班、郭和曾。

Various trials have demonstrated the clinical benefits of lenvatinib plus pembrolizumab in patients with advanced or recurrent endometrial cancer, regardless of mismatch repair (MMR) status or histologic subtype. The majority of the previously published trials had small sample sizes. Here, we aimed to assess the reported efficacy and safety profile of lenvatinib plus pembrolizumab in patients with advanced and recurrent endometrial cancer.We utilized the Cochrane Library, PubMed, Web of Science and Embase databases to identify clinical trials evaluating the efficacy and safety of lenvatinib plus pembrolizumab in patients with advanced and recurrent endometrial cancer. The outcomes analyzed were progression-free survival (PFS), overall survival (OS), the objective response rate (ORR), the disease control rate (DCR) and the incidence of adverse events (AEs). Subgroup analysis was conducted on the basis of MMR status (deficient, dMMR or proficient, pMMR).Four trials (582 patients) were included. The pooled ORR was 32.7% [95% confidence interval (CI): 28.9-36.5]. Subgroup analysis revealed an ORR of 48.1% (95% CI: 26.1-70.2) for dMMR group and 33.1% (95% CI: 25.7-40.6) for pMMR group. The pooled DCR was 74.9% (95% CI: 71.3-78.4%). Subgroup analysis revealed a DCR of 81.0% (95% CI: 64.5-97.6) for the dMMR group and 76.3% (95% CI: 66.3-86.3) for the pMMR group. Follow-up was reported in all included studies. The median range time of PFS and OS was 5.3 months-258 days and 17.2 months-not reached, respectively. Regarding safety, the overall pooled proportions of any-grade AE and AEs ≥ grade 3 were 95.8% (95% CI: 89.5-100.0) and 80.2% (95% CI: 59.9-100.0), respectively.Lenvatinib plus pembrolizumab showed a relevant clinical benefit and significant toxicity in patients with advanced and recurrent endometrial cancer. Further studies encompassing long-term outcomes are warranted.https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=522160/, identifier CRD42024522160.Copyright © 2024 Yan, Du, Zhang, Yan, Liu, Ban, Guo and Zeng.