微生物群与胶质瘤：从相关性到临床转化的新视角
Microbiota and glioma: a new perspective from association to clinical translation
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影响因子:11
分区:医学1区 Top / 微生物学1区 胃肠肝病学2区
发表日期:2024
作者:
Wenhui Wang, Zihao Ou, Xixin Huang, Jingyu Wang, Qianbei Li, Minghui Wen, Lei Zheng
DOI:
10.1080/19490976.2024.2394166
摘要
胶质瘤在肿瘤学中构成重大挑战，因其恶性特性、侵袭性增长、频繁复发以及血脑屏障带来的并发症。新兴研究揭示肠道微生物群在影响健康与疾病中的关键作用，提示其可能影响胶质瘤的发病机制及治疗反应。本文综述了微生物群与胶质瘤从进展到侵袭的关系的现有证据和假设。通过探讨微生物群可能影响胶质瘤生物学的潜在机制，为肿瘤学中的靶向治疗和精准医疗开辟了新途径。
Abstract
Gliomas pose a significant challenge in oncology due to their malignant nature, aggressive growth, frequent recurrence, and complications posed by the blood-brain barrier. Emerging research has revealed the critical role of gut microbiota in influencing health and disease, indicating its possible impact on glioma pathogenesis and treatment responsiveness. This review focused on existing evidence and hypotheses on the relationship between microbiota and glioma from progression to invasion. By discussing possible mechanisms through which microbiota may affect glioma biology, this paper offers new avenues for targeted therapies and precision medicine in oncology.