研究动态
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微生物群和神经胶质瘤:从关联到临床转化的新视角。

Microbiota and glioma: a new perspective from association to clinical translation.

发表日期:2024
作者: Wenhui Wang, Zihao Ou, Xixin Huang, Jingyu Wang, Qianbei Li, Minghui Wen, Lei Zheng
来源: Gut Microbes

摘要:

神经胶质瘤由于其恶性性质、侵袭性生长、频繁复发以及血脑屏障引起的并发症,对肿瘤学提出了重大挑战。新兴研究揭示了肠道微生物群在影响健康和疾病方面的关键作用,表明其可能对神经胶质瘤发病机制和治疗反应产生影响。本综述重点关注微生物群与神经胶质瘤从进展到侵袭之间关系的现有证据和假设。通过讨论微生物群影响神经胶质瘤生物学的可能机制,本文为肿瘤学中的靶向治疗和精准医学提供了新途径。
Gliomas pose a significant challenge in oncology due to their malignant nature, aggressive growth, frequent recurrence, and complications posed by the blood-brain barrier. Emerging research has revealed the critical role of gut microbiota in influencing health and disease, indicating its possible impact on glioma pathogenesis and treatment responsiveness. This review focused on existing evidence and hypotheses on the relationship between microbiota and glioma from progression to invasion. By discussing possible mechanisms through which microbiota may affect glioma biology, this paper offers new avenues for targeted therapies and precision medicine in oncology.