微生物群和神经胶质瘤：从关联到临床翻译的新观点
Microbiota and glioma: a new perspective from association to clinical translation
影响因子:11.00000
分区:医学1区 Top / 微生物学1区 胃肠肝病学2区
发表日期:2024
作者:
Wenhui Wang, Zihao Ou, Xixin Huang, Jingyu Wang, Qianbei Li, Minghui Wen, Lei Zheng
摘要
神经胶质瘤由于其恶性，侵略性生长，频繁复发和血脑屏障带来的并发症，对肿瘤学构成了重大挑战。新兴研究揭示了肠道菌群在影响健康和疾病的关键作用，表明它可能对神经胶质瘤的发病机理和治疗反应能力产生影响。这篇综述的重点是现有证据和关于从进展到入侵的微生物瘤与神经胶质瘤之间关系的假设。通过讨论微生物群可能影响神经胶质瘤生物学的可能机制，本文为肿瘤学中有针对性疗法和精确医学提供了新的途径。
Abstract
Gliomas pose a significant challenge in oncology due to their malignant nature, aggressive growth, frequent recurrence, and complications posed by the blood-brain barrier. Emerging research has revealed the critical role of gut microbiota in influencing health and disease, indicating its possible impact on glioma pathogenesis and treatment responsiveness. This review focused on existing evidence and hypotheses on the relationship between microbiota and glioma from progression to invasion. By discussing possible mechanisms through which microbiota may affect glioma biology, this paper offers new avenues for targeted therapies and precision medicine in oncology.