缺血性心脏病严重威胁人类健康，甚至导致死亡。 Kirenol 主要源自豨莶草植物，具有广泛的生物效应（如抗菌、抗炎、抗癌和心脏保护）。然而，kirenol 在心肌缺血/再灌注损伤（MI/RI）中的调节作用和相关机制仍不清楚。本研究首先建立MI/RI大鼠模型。结果表明，kirenol 可防止 MI/RI 大鼠心功能恶化。此外，炎症是由缺血再灌注（IR）引起的，同样也受到基雷诺（kirenol）（5或10 mg/kg）的影响。此外，红外线还会增强氧化应激，而这一过程可被 kirenol 抵消。接下来，发现 IR 后细胞凋亡增加，但这种效应被 kirenol 中和。最后，人们发现 kirenol 具有阻断 NF-κB 通路激活的能力。总之，kirenol 通过调节 NF-κB 通路减轻炎症和氧化应激，从而改善大鼠的 MI/RI。这项工作可能为寻找治疗 MI/RI 的有用药物提供新颖的见解。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。

The ischemic heart disease gravely threatens human health and even results in death. Kirenol is predominantly derived from the Herba Siegesbeckiae plant species and possesses a wide range of biological effects (such as antibacterial, anti-inflammatory, anti-cancer and cardioprotective). However, the regulatory effects and associated mechanisms of kirenol in myocardial ischemia/reperfusion injury (MI/RI) remain unclear. In this study, firstly, the MI/RI rat model was established. It was demonstrated that kirenol protected against the aggravation of cardiac function in MI/RI rats. In addition, the inflammation was induced by ischemia reperfusion (IR), which was likewise affected by kirenol (5 or 10 mg/kg). Moreover, IR enhanced oxidative stress, a process that was counteracted by kirenol. Next, cell apoptosis was discovered to be heightened after IR, but this effect was neutralized by kirenol. Finally, it was uncovered that kirenol has the ability to block the activation of the NF-κB pathway. In conclusion, it was disclosed that kirenol alleviated inflammation and oxidative stress through modulating the NF-κB pathway to improve MI/RI in rats. This work may offer novel insights for searching useful drugs for treating MI/RI.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.