肿瘤消化物：巨噬细胞代谢对 T 细胞形成屏障。
Tumour's Digest: Macrophage metabolism creates a barrier to T cells.
发表日期：2024 Aug 26
作者：
Eleanor Jane Tyler, Oliver M T Pearce
来源：
CANCER RESEARCH
摘要：
肿瘤细胞外基质的组成和物理性质的变化与细胞毒性 T 细胞浸润和治疗反应不佳有关，但其潜在机制仍不清楚。 Tharp 及其同事揭示了一个令人着迷的级联反应，其中肿瘤纤维化改变了巨噬细胞的代谢，限制了可用于浸润 T 细胞的营养物质，导致它们被抑制并被排除在肿瘤微环境之外。这项研究表明，靶向代谢途径可能是克服肿瘤细胞外基质诱导的免疫抑制的一种有前途的策略。
Changes in the composition and physical properties of the tumor extracellular matrix are linked to poor cytotoxic T-cell infiltration and therapy response, yet the underlying mechanisms remain unclear. Tharp and colleagues revealed a fascinating cascade where tumor fibrosis alters macrophage metabolism, restricting the nutrients available to infiltrating T-cells and resulting in their suppression and exclusion from the tumor microenvironment. This study suggests that targeting metabolic pathways could be a promising strategy to overcome the immune suppression induced by the tumor extracellular matrix.