用于发现抗癌抗体的噬菌体展示。
Phage display for discovery of anticancer antibodies.
发表日期：2024 Aug 24
作者：
Polina V Istomina, Andrey A Gorchakov, Chatchanok Paoin, Montarop Yamabhai
来源：
New Biotechnology
摘要：
抗体和基于抗体的免疫治疗是癌症免疫治疗的支柱。扩大抗体可靶向的癌症特异性和癌症相关表位的库是一个重要的研究领域。噬菌体展示是一种强大的方法，允许使用不同的抗体库来筛选与各种靶标的结合。在这篇综述中，我们总结了噬菌体展示技术的基础知识，并重点介绍了通过噬菌体展示平台进行抗癌抗体鉴定和修饰的进展。最后，我们描述了迄今为止已获批准或正在进行临床开发的噬菌体展示衍生的抗癌单克隆抗体。版权所有 © 2024 作者。由 Elsevier B.V. 出版。保留所有权利。
Antibodies and antibody-based immunotherapeutics are the mainstays of cancer immunotherapy. Expanding the repertoire of cancer-specific and cancer-associated epitopes targetable with antibodies represents an important area of research. Phage display is a powerful approach allowing the use of diverse antibody libraries to be screened for binding to a wide range of targets. In this review, we summarize the basics of phage display technology and highlight the advances in anticancer antibody identification and modification via phage display platform. Finally, we describe phage display-derived anticancer monoclonal antibodies that have been approved to date or are in clinical development.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.