CA-125 检测是建议在英国初级保健中对可能出现卵巢癌症状的女性进行的一线检查，以帮助确定是否需要进一步检查卵巢癌。目前尚不清楚 CA-125 测试在不同种族患者的卵巢癌检测中的表现如何。利用与国家癌症登记处相关的英国初级保健数据进行了一项回顾性队列研究。纳入 2010 年至 2017 年间进行过 CA-125 测试的年龄≥40 岁的女性。逻辑回归预测了按种族划分的一年卵巢癌发病率，并调整了年龄、剥夺状态和合并症评分。使用限制三次样条对每个种族群体的 CA-125 水平估计的卵巢癌发病率进行建模。CA-125 的诊断性能对于不同种族的女性有所不同。在一项未经调整的分析中，在相应的卵巢癌概率下，亚洲和黑人女性的预测 CA-125 水平高于白人女性。与亚洲或黑人女性相比，白人女性较高的 PPV 通过包含协变量而被消除。种族特异性阈值的引入可能会增加 CA-125 在卵巢癌检测中的特异性和 PPV，但会牺牲敏感性，特别是对于亚洲和黑人女性黑人女性。因此，我们不建议对 CA-125 使用特定于种族的阈值。© 2024。作者。

CA-125 testing is a recommended first line investigation for women presenting with possible symptoms of ovarian cancer in English primary care, to help determine whether further investigation for ovarian cancer is needed. It is currently not known how well the CA-125 test performs in ovarian cancer detection for patients from different ethnic groups.A retrospective cohort study utilising English primary care data linked to the national cancer registry was undertaken. Women aged ≥ 40 years with a CA-125 test between 2010 and 2017 were included. Logistic regression predicted one-year ovarian cancer incidence by ethnicity, adjusting for age, deprivation status, and comorbidity score. The estimated incidence of ovarian cancer by CA-125 level was modelled for each ethnic group using restricted cubic splines.The diagnostic performance of CA-125 differed for women from different ethnicities. In an unadjusted analysis, predicted CA-125 levels for Asian and Black women were higher than White women at corresponding probabilities of ovarian cancer. The higher PPVs for White women compared to Asian or Black women were eliminated by inclusion of covariates.The introduction of ethnicity-specific thresholds may increase the specificity and PPVs of CA-125 in ovarian cancer detection at the expense of sensitivity, particularly for Asian and Black women. As such, we cannot recommend the use of ethnicity-specific thresholds for CA-125.© 2024. The Author(s).