有证据表明，与普通人群相比，癌症患者更容易患高尿酸血症（HUA），其中脂质代谢起着重要作用。然而，目前尚不清楚这些患者的非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值（NHHR）和HUA之间是否存在非线性关系。本研究旨在探讨癌症患者中 NHHR 与 HUA 之间的关联。本研究纳入了 2007 年至 2018 年 NHANES 数据库中的参与者。我们使用多变量逻辑回归、限制三次样条 (RCS) 分析和亚组分析来检查 NHHR 与 HUA 之间的关联。癌症患者中的 NHHR 和 HUA 与痛风，以及调查特定亚组之间这种关联的差异。总共纳入 2826 名参与者，HUA 患病率为 24.30%。加权多变量逻辑回归显示，NHHR 每增加一个单位，癌症患者发生 HUA 的几率增加 16%（95% 置信区间 [CI]：1.06、1.29，P = 0.002）。当 NHHR 分为三分位时，最高三分位 (Q3) 的患者发生 HUA 的几率是最低三分位 (Q1) 的患者的 1.84 倍 (95% CI: 1.32, 2.58, P < 0.001)。然而，与痛风没有显着关联。 RCS 分析进一步揭示了显着的非线性正相关性，尤其是在男性中。亚组分析和相互作用测试表明，在没有中风病史的癌症患者中存在更强的关联。癌症患者中 NHHR 和 HUA 之间存在非线性关联。© 2024。作者。

Evidence shows that cancer patients are more likely to have hyperuricemia (HUA) compared to the general population, with lipid metabolism playing a significant role. However, it is still unclear whether there is a non-linear relationship between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and HUA in these patients. This study aims to explore the association between NHHR and HUA in cancer patients.This study included participants from the NHANES database from 2007 to 2018. We used multivariable logistic regression, restricted cubic splines (RCS) analysis, and subgroup analysis to examine the association between NHHR and HUA and gout in cancer patients, as well as to investigate differences in this association among specific subgroups.A total of 2826 participants were included, with a HUA prevalence of 24.30%. Weighted multivariable logistic regression showed that for each unit increase in NHHR, the odds of HUA in cancer patients increased by 16% (95% confidence interval [CI]: 1.06, 1.29, P = 0.002). When NHHR was divided into tertiles, those in the highest tertile (Q3) had a 1.84 times higher odds of developing HUA compared to those in the lowest tertile (Q1) (95% CI: 1.32, 2.58, P < 0.001). However, there was no significant association with gout. RCS analysis further revealed a significant non-linear positive association, particularly among males. Subgroup analysis and interaction tests indicated a stronger association in cancer patients who did not have a history of stroke.There is a non-linear association between NHHR and HUA in cancer patients.© 2024. The Author(s).