胸腺瘤脑转移：罕见继发性定位病例报告。
Brain metastases from a thymoma: Case report for a rare secondary localization.
发表日期：2024 Oct
作者：
Ghassen Gader, Skander Guediche, Ines Moussa, Sinda Ben Zekri, Mohamed Badri, Ahmed Harbaoui, Ihsèn Zammel
来源：
Burns & Trauma
摘要：
胸腺瘤是起源于胸腺的良性上皮肿瘤，是最常见的原发性纵隔肿瘤之一。恶性肿瘤通常是通过包膜外病理浸润的证据来确定的，局部浸润是扩散到邻近器官的主要模式。远处转移极为罕见。我们介绍了一名 63 岁男性的病例，他表现出颅内压增高和运动缺陷的症状。脑部成像显示多处颅内病变。进行手术干预以切除最大的病变。随后的全身CT扫描和病理检查证实脑转移瘤起源于原发性胸腺瘤，分类为B3。患者被建议接受辅助化疗和放疗，但不幸的是在治疗开始时就去世了。胸腺瘤脑转移患者的预后仍然很差。最佳管理策略通常包括在可行的情况下立即进行手术干预，然后进行旨在提高平均生存率的辅助治疗。© 2024 作者。由爱思唯尔公司代表华盛顿大学出版。
Thymomas are benign epithelial neoplasms originating from the thymus gland and are among the most common primary mediastinal tumors. Malignancy is typically determined by evidence of pathological invasion beyond the capsule, with local invasion being the primary mode of spread to adjacent organs. Distant metastases are exceedingly rare. We present the case of a 63-year-old man who exhibited symptoms suggestive of increased intracranial pressure and motor deficit. Brain imaging revealed multiple intracranial lesions. Surgical intervention was performed to excise the largest lesion. Subsequent body CT scan and pathological examination confirmed that the brain metastases originated from a primary thymoma, classified as B3. The patient was recommended for adjuvant chemotherapy and radiotherapy, but unfortunately passed away at the initiation of therapy. The prognosis for patients with brain metastases from thymomas remains poor. Optimal management strategies typically involve prompt surgical intervention whenever feasible, followed by adjuvant therapy aimed at improving mean survival rates.© 2024 The Authors. Published by Elsevier Inc. on behalf of University of Washington.