癌症的发病率在全世界范围内不断增加，并且是最常见的死亡原因。鉴定新型癌症诊断和预后生物标志物对于制定癌症治疗策略和降低死亡率非常重要。细胞周期蛋白依赖性激酶亚基2（CKS2）参与细胞周期和增殖过程，基于这些过程，CKS2被鉴定为癌症基因。 CKS2在人体多种组织中表达，但其异常表达与多种系统的癌症相关。 CKS2在癌症中普遍升高，通过调节某些重要基因的多种机制在癌症生物学的几乎所有方面（例如细胞增殖、侵袭、转移和耐药）发挥作用，并且与患者的临床病理特征相关。此外，CKS2表达模式与癌症类型、分期和其他临床变量密切相关。因此，CKS2被认为是癌症诊断和预后的工具，并可能是一个有前途的肿瘤生物标志物和治疗靶点。本文对CKS2在癌症中的生物学功能、作用机制及潜在临床意义进行综述，以期为癌症的临床分子诊断、分子靶向治疗和科学研究提供新的理论依据。Copyright © 2024 Lai and Lin.

The incidence of cancer is increasing worldwide and is the most common cause of death. Identification of novel cancer diagnostic and prognostic biomarkers is important for developing cancer treatment strategies and reducing mortality. Cyclin-dependent kinase subunit 2 (CKS2) is involved in cell cycle and proliferation processes, and based on these processes, CKS2 was identified as a cancer gene. CKS2 is expressed in a variety of tissues in the human body, but its abnormal expression is associated with cancer in a variety of systems. CKS2 is generally elevated in cancer, plays a role in almost all aspects of cancer biology (such as cell proliferation, invasion, metastasis, and drug resistance) through multiple mechanisms regulating certain important genes, and is associated with clinicopathological features of patients. In addition, CKS2 expression patterns are closely related to cancer type, stage and other clinical variables. Therefore, CKS2 is considered as a tool for cancer diagnosis and prognosis and may be a promising tumor biomarker and therapeutic target. This article reviews the biological function, mechanism of action and potential clinical significance of CKS2 in cancer, in order to provide a new theoretical basis for clinical molecular diagnosis, molecular targeted therapy and scientific research of cancer.Copyright © 2024 Lai and Lin.