细胞外腺苷 (eAdo) 连接肿瘤代谢和免疫调节。 CD39-CD73-eAdo/A2aR 轴调节肿瘤微环境 (TME) 和免疫治疗反应。在免疫治疗时代，探索CD39-CD73-eAdo/A2aR轴对TME的影响并开发靶向治疗药物以增强免疫治疗的疗效是当前的研究热点。本研究对腺苷轴在TME领域的研究趋势和热点进行了总结和探讨，为进一步深入研究提供思路。文献信息来源于Web of Science核心合集数据库。利用VOS查看器和基于R的文献计量工具，通过分析全球年度发表量、国家/地区和机构分布、文章作者和共被引作者、期刊的详细信息，量化识别合作信息和个人影响力这些文章的分发。同时分析CD39-CD73-eAdo/A2aR在TME领域的作者关键词分布及作者关键词共现情况、高被引文章、高同被引参考文献的情况，以确定研究热点和趋势.1,721篇过去十年发表的文章被纳入本研究。通过文献计量分析，我们发现：（1）69个国家和地区探讨了CD39-CD73-eAdo/A2aR对TME的影响，且研究总体呈上升趋势。美国研究人员在该领域的研究中占据主导地位，总引用率最高。中国的出版物数量最多。 (2)哈佛大学在该领域发表的文章最多。 (3) 12,065位作者在该领域发表了论文，其中23位作者发表了至少8篇论文。 STAGG J具有显着的学术影响力，发表文章24篇，被引用2,776次。共同被引的作者可以分为三类。 Stagg J、Allard B、Ohta A 和 Antonioli, L 在网络中占据中心位置。 (4) 579种学术期刊发表了该领域的文章。发表论文数量最多的是《FRONTIERS IN IMMUNOLOGY》杂志，共 97 篇，共被引用 2,317 次，且发表数量逐年增加。 （5）“The ectonucleotidase CD39 and CD73: Novel checkpoint irrehibitor Targets”为本地被引次数最多的文章（163次）。 “A2A 腺苷受体保护肿瘤免受抗肿瘤 T 细胞的侵害”是共被引用次数最多的参考文献（224 次）。 (6)通过作者关键词分析，我们发现腺苷与免疫治疗的关系是该领域许多研究者的核心概念。乳腺癌、黑色素瘤、结直肠癌、卵巢癌、胶质母细胞瘤、胰腺癌、肝细胞癌和肺癌是腺苷相关肿瘤研究中最常见的癌症类型。免疫治疗、免疫抑制、免疫检查点、免疫检查点抑制剂是研究热点关键词，体现了腺苷代谢途径在肿瘤免疫治疗中的重要性。免疫原性细胞死亡、T细胞、Sting、调节性T细胞、先天免疫和免疫浸润等关键词展示了腺苷影响TME的途径。近年来著名作者关键词有免疫治疗、免疫原性细胞死亡、炎症、肺癌、胃癌。CD39-CD73-eAdo/A2aR对TME中多种免疫细胞浸润和功能的影响，肿瘤免疫治疗反应，患者预后已引起许多国家/地区研究人员的关注。美国学者在这一领域的研究仍占主导地位，但中国学者的研究成果最多。 《免疫学前沿》杂志发表了该领域最丰富的研究成果。 Stagg J 是该领域极具影响力的研究者。进一步探索靶向抑制CD39-CD73-eAdo/A2aR单独或联合其他免疫疗法、放疗、化疗治疗各种癌症类型并开发有效的临床治疗药物是该领域持续的研究热点。 版权所有 © 2024 黄任、唐、王、季、郭、马、郑、胡、周。

Extracellular adenosine (eAdo) bridges tumor metabolism and immune regulation. CD39-CD73-eAdo/A2aR axis regulates tumor microenvironment (TME) and immunotherapy response. In the era of immunotherapy, exploring the impact of the CD39-CD73-eAdo/A2aR axis on TME and developing targeted therapeutic drugs to enhance the efficacy of immunotherapy are the current research hotspots. This study summarizes and explores the research trends and hotspots of the adenosine axis in the field of TME to provide ideas for further in-depth research.Literature information was obtained from the Web of Science core collection database. The VOS viewer and the bibliometric tool based on R were used to quantify and identify cooperation information and individual influence by analyzing the detailed information of the global annual publication volume, country/region and institution distribution, article authors and co-cited authors, and journal distribution of these articles. At the same time, the distribution of author keywords and the co-occurrence of author keywords, highly cited articles, and highly co-cited references of CD39-CD73-eAdo/A2aR in the field of TME were analyzed to determine research hotspots and trends.1,721 articles published in the past ten years were included in this study. Through bibliometric analysis, we found that (1) 69 countries and regions explored the effect of the CD39-CD73-eAdo/A2aR on TME, and the research was generally on the rise. Researchers in the United States dominated research in this area, with the highest total citation rate. China had the most significant number of publications. (2) Harvard University has published the most articles in this field. (3) 12,065 authors contributed to the publication of papers in this field, of which 23 published at least eight papers. STAGG J had significant academic influence, with 24 published articles and 2,776 citations. Co-cited authors can be clustered into three categories. Stagg J, Allard B, Ohta A, and Antonioli, L occupied a central position in the network. (4) 579 scholarly journals have published articles in this field. The journal FRONTIERS IN IMMUNOLOGY published the most significant number of papers, with 97 articles and a total of 2,317 citations, and the number of publications increased year by year. (5) "The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets" was the most frequently local cited article (163 times). The "A2A adenosine receptor protects tumors from antitumor T cells" was the most co-cited reference (224 times). (6) Through the analysis of author keywords, we found that the relationship between adenosine and immunotherapy was a core concept for many researchers in this field. Breast cancer, melanoma, colorectal cancer, ovarian cancer, glioblastoma, pancreatic cancer, hepatocellular carcinoma, and lung cancer were the most frequent cancer types in adenosine-related tumor studies. Immunotherapy, immunosuppression, immune checkpoint, and immune checkpoint inhibitors were the hot keywords in the research, reflecting the importance of the adenosine metabolic pathway in tumor immunotherapy. The keywords such as Immunogenic cell death, T cells, Sting, regulatory T cells, innate immunity, and immune infiltration demonstrated the pathways by which adenosine affected the TME. The famous author keywords in recent years have been immunotherapy, immunogenic cell death, inflammation, lung cancer, and gastric cancer.The effect of CD39-CD73-eAdo/A2aR on the infiltration and function of various immune cells in TME, tumor immunotherapy response, and patient prognosis has attracted the attention of researchers from many countries/regions. American scholars still dominate the research in this field, but Chinese scholars produce the most research results. The journal FRONTIERS IN IMMUNOLOGY has published the wealthiest research in the field. Stagg J was a highly influential researcher in this field. Further exploration of targeted inhibition of CD39-CD73-eAdo/A2aR alone or in combination with other immunotherapy, radiotherapy, and chemotherapy in treating various cancer types and developing effective clinical therapeutic drugs are continuous research hotspots in this field.Copyright © 2024 Huang, Ren, Tang, Wang, Ji, Guo, Ma, Zheng, Hu and Zhou.