纳米技术的出现为疫苗研究注入了新的活力。近年来，纳米疫苗研究呈指数级增长；然而，对相关出版物的全面分析却明显缺乏。本研究利用文献计量方法来揭示主题的演变和纳米疫苗研究的分布。使用VOSviewer、CiteSpace、Scimago Graphica、Pajek、R-bibliometrix和R等工具用于对从 Web of Science 数据库检索到的文献进行文献计量分析和可视化的软件包。纳米疫苗研究始于 1981 年。出版量呈指数级增长，尤其是在 2021 年。主要贡献者包括美国、中国科学院、《疫苗》杂志，以及赵凯研究员。其他重要贡献者包括中国、加州大学圣地亚哥分校、Veronique Preat、《受控释放杂志》和中国国家自然科学基金会。美国是国际合作的中心枢纽。财政支持在推动研究进步方面发挥着关键作用。被高引用文章的关键主题包括疫苗载体设计、癌症疫苗、纳米材料特性和 COVID-19 疫苗。 7402个关键词中，主要的纳米载体包括壳聚糖、病毒样颗粒、纳米金、PLGA、脂质纳米颗粒等。纳米疫苗主要用于治疗 SARS-CoV-2、癌症、流感和 HIV 等疾病。同被引网络的聚类分析确定了 9 个主要聚类，生动地说明了不同时期研究主题的演变。同引爆发表明癌症疫苗、COVID-19 疫苗和 mRNA 疫苗是纳米疫苗当前和未来研究的关键领域。 “候选疫苗”、“蛋白质纳米颗粒”、“阳离子脂质”、“可电离脂质”、“机器学习”、“长期储存”、“个性化癌症疫苗”、“新抗原”、“外膜囊泡”、“ “原位纳米疫苗”和“仿生纳米技术”成为研究热点。该分析强调了纳米疫苗研究日益增长的学术兴趣，并强调了癌症和 COVID-19 疫苗等近期的关键研究主题，其中脂质纳米颗粒-mRNA 疫苗引领了新的研究方向.版权所有 © 2024 吴、刘、张、罗、王、乔和刘。

The emergence of nanotechnology has injected new vigor into vaccine research. Nanovaccine research has witnessed exponential growth in recent years; yet, a comprehensive analysis of related publications has been notably absent.This study utilizes bibliometric methodologies to reveal the evolution of themes and the distribution of nanovaccine research.Using tools such as VOSviewer, CiteSpace, Scimago Graphica, Pajek, R-bibliometrix, and R packages for the bibliometric analysis and visualization of literature retrieved from the Web of Science database.Nanovaccine research commenced in 1981. The publication volume exponentially increased, notably in 2021. Leading contributors include the United States, the Chinese Academy of Sciences, the "Vaccine", and researcher Zhao Kai. Other significant contributors comprise China, the University of California, San Diego, Veronique Preat, the Journal of Controlled Release, and the National Natural Science Foundation of China. The USA functions as a central hub for international cooperation. Financial support plays a pivotal role in driving research advancements. Key themes in highly cited articles include vaccine carrier design, cancer vaccines, nanomaterial properties, and COVID-19 vaccines. Among 7402 keywords, the principal nanocarriers include Chitosan, virus-like particles, gold nanoparticles, PLGA, and lipid nanoparticles. Nanovaccine is primarily intended to address diseases including SARS-CoV-2, cancer, influenza, and HIV. Clustering analysis of co-citation networks identifies 9 primary clusters, vividly illustrating the evolution of research themes over different periods. Co-citation bursts indicate that cancer vaccines, COVID-19 vaccines, and mRNA vaccines are pivotal areas of focus for current and future research in nanovaccines. "candidate vaccines," "protein nanoparticle," "cationic lipids," "ionizable lipids," "machine learning," "long-term storage," "personalized cancer vaccines," "neoantigens," "outer membrane vesicles," "in situ nanovaccine," and "biomimetic nanotechnologies" stand out as research interest.This analysis emphasizes the increasing scholarly interest in nanovaccine research and highlights pivotal recent research themes such as cancer and COVID-19 vaccines, with lipid nanoparticle-mRNA vaccines leading novel research directions.Copyright © 2024 Wu, Liu, Zhang, Luo, Wang, Qiao and Liu.