小檗碱 (BBR) 被认为是一种肿瘤治疗植物化学物质，通过多种分子途径展现其抗癌特性。然而，其临床应用受到肿瘤累积欠佳、快速全身消除以及由于广泛的代谢降解而导致的生物活性浓度降低的阻碍。为了规避这些限制，纳米载体和其他药物与 BBR 结合的战略应用正在成为增强其抗癌功效的焦点。这篇综述介绍了 BBR 的广泛抗癌活性、BBR 和其他药物共同负载的纳米载体用于抗癌治疗，并评估了这些混合方式的协同增强作用。目的是概述基于纳米递送的 BBR 用于癌症治疗。小檗碱 (BBR) 被认为是一种肿瘤治疗植物化学物质，通过多种分子途径展现其抗癌特性。然而，其临床应用受到肿瘤累积欠佳、快速全身消除以及由于广泛的代谢降解而导致的生物活性浓度降低的阻碍。为了规避这些限制，纳米载体和其他药物与 BBR 结合的战略应用正在成为增强其抗癌功效的焦点。纳米递送系统通过改善药理活性和组织分布来增加肿瘤部位的药物浓度，从而增强药物的生物利用度。有机纳米载体在小檗碱递送方面具有优势，包括生物相容性、封装性和药物的控制释放。而无机纳米载体用于小檗碱递送的优势主要在于其对药物的高效负载能力和药物的缓释能力。这篇综述介绍了 BBR 的广泛抗癌活性、BBR 和其他药物共同负载的纳米载体用于抗癌治疗，并评估了这些混合方式的协同增强作用。目的是提供基于纳米递送的 BBR 用于癌症治疗的概述。© 2024 Sun 等人。

Berberine (BBR), recognized as an oncotherapeutic phytochemical, exhibits its anti-cancer properties via multiple molecular pathways. However, its clinical application is hindered by suboptimal tumor accumulation, rapid systemic elimination, and diminished bioactive concentration owing to extensive metabolic degradation. To circumvent these limitations, the strategic employment of nanocarriers and other drugs in combination with BBR is emerging as a focus to potentiate its anti-cancer efficacy. This review introduced the expansive spectrum of BBR's anti-cancer activities, BBR and other drugs co-loaded nanocarriers for anti-cancer treatments, and evaluated the synergistic augmentation of these amalgamated modalities. The aim is to provide an overview of BBR for cancer treatment based on nano-delivery. Berberine (BBR), recognized as an oncotherapeutic phytochemical, exhibits its anti-cancer properties via multiple molecular pathways. However, its clinical application is hindered by suboptimal tumor accumulation, rapid systemic elimination, and diminished bioactive concentration owing to extensive metabolic degradation. To circumvent these limitations, the strategic employment of nanocarriers and other drugs in combination with BBR is emerging as a focus to potentiate its anti-cancer efficacy. Nano-delivery systems increase drug concentration at the tumor site by improving pharmacological activity and tissue distribution, enhancing drug bioavailability. Organic nanocarriers have advantages for berberine delivery including biocompatibility, encapsulation, and controlled release of the drug. While the advantages of inorganic nanocarriers for berberine delivery mainly lie in their efficient loading ability of the drug and their slow release ability of the drug. This review introduced the expansive spectrum of BBR's anti-cancer activities, BBR and other drugs co-loaded nanocarriers for anti-cancer treatments, and evaluated the synergistic augmentation of these amalgamated modalities. The aim is to provide an overview of BBR for cancer treatment based on nano-delivery.© 2024 Sun et al.