简介：甲状腺疾病、糖尿病（DM）和多囊卵巢综合征（PCOS）等内分泌问题的治疗面临着巨大的挑战，全世界的医疗专业人员都在努力寻找新的治疗方法。然而，除了药物、激素替代疗法和手术等常见治疗方法外，人们对激光疗法等替代疗法越来越感兴趣，它提供了一种非侵入性的独特技术，可以单独或与传统方法结合治疗内分泌疾病。本综述的主要目的是对激光和微波在治疗内分泌疾病中的作用进行系统评价。方法：在本系统综述中，检索了最重要的数据库，包括 PubMed、Scopus 和 Google Scholar，查找 1995 年至 2023 年使用适当的关键词和具体策略检验激光治疗内分泌问题效果的研究。与激光和内分泌无关的研究被排除在外。结果：基于 51 项审查研究，激光和射频消融（例如 RFA）可有效治疗甲状腺疾病、甲状旁腺功能亢进、胰腺疾病和性功能障碍。激光诱导间质热疗 (LITT) 和微波消融 (MWA) 是真正的微创方法，用于治疗良性结节、腺瘤和肿瘤消融，包括胰腺癌和肾上腺肿瘤。使用红光、紫外线和蓝光的静脉激光血液照射 (ILBI) 可有效治疗各种代谢性疾病，例如糖尿病。结论：激光作为一种尖端、微创的方法可以治疗多种内分泌疾病。它在治疗和调节荷尔蒙失衡、减少炎症和缓解内分泌失调等各种疾病的症状方面具有巨大潜力。版权所有 © 2024 J Lasers Med Sci。

Introduction: The treatment of endocrine problems like thyroid disease, diabetes mellitus (DM), and polycystic ovary syndrome (PCOS) faces significant challenges so that medical professionals worldwide try to find a new therapeutic approach. However, along with common treatments which include medications, hormone replacement therapy, and surgery; there is a growing interest in alternative therapies like laser therapy, which offers a non-invasive and unique technique for treating endocrine disorders alone or in combination with traditional methods. The main goal of this review was to do a systematic review on the role of the laser and Microwave in the treatment endocrine disorders. Methods: In the present systematic review, the most important databases, including PubMed, Scopus and Google Scholar, were searched for the studies examining the effect of lasers on the treatment of endocrine problems by using appropriate keywords and specific strategies from 1995 to 2023. All the studies that were not about lasers and endocrine were excluded. Results: Based on 51 reviewed studies, lasers and radiofrequency ablation such as RFA are effective in the treatment of thyroid diseases, hyperparathyroidism, pancreatic disorders, and sexual dysfunctions. Laser-induced interstitial thermal therapy (LITT) and microwave ablation (MWA) are genuine minimally invasive methods for the treatment of benign nodules, adenomas, and tumor ablation including pancreatic carcinomas and adrenal tumors. Intravenous laser blood irradiation (ILBI) which uses red, UV, and blue light could be effective in treating various metabolic disorders, such as DM. Conclusion: Laser as a cutting-edge and minimally invasive approach could treat various endocrine disorders. It has a great potential to treat and regulate hormonal imbalances, decrease inflammation, and relieve symptoms of various ailments, such as endocrine disorders.Copyright © 2024 J Lasers Med Sci.