炎症是多细胞生物体由损伤、病原体或刺激物引起的生物反应。过度的炎症反应会导致组织损伤和各种慢性疾病。慢性炎症是许多疾病的共同特征，因此迫切需要寻找治疗炎症相关疾病的药物。灯盏花乙素是一种天然黄酮代谢物，因其抗炎、抗氧化和抗癌活性而广泛用于治疗各种炎症相关疾病。灯盏花乙素可抑制关键炎症通路（PI3K/Akt、MAPK、NF-κB等）并激活抗氧化相关通路（Nrf2、ARE等），从而保护组织免受炎症和氧化应激的影响。现代提取技术，如微波辅助、超声辅助和超临界流体萃取，已用于从黄芩属和灯盏花属中提取灯盏乙素。这些技术提高了效率并保留了生物活性，使灯盏花乙素适合大规模生产。灯盏花乙素对于治疗骨关节炎、肺纤维化、肾损伤、心血管疾病等具有显着的治疗作用。但由于其生物利用度低、半衰期短，其临床应用受到限制。研究人员正在探索创新配方（β-环糊精聚合物、甘油三酯模拟活性成分和脂质体前体等）以提高稳定性和吸收率。尽管存在这些挑战，灯盏花乙素在抗炎、抗氧化和抗癌应用中的潜力仍然巨大。通过优化剂型、探索联合疗法、深入开展机理研究，灯盏花乙素可以在治疗多种炎症性疾病中发挥重要作用，为患者提供更多、更有效的治疗选择。版权所有 © 2024 周顾朱朱朱陈施、杨、卢、庞。

Inflammation is a biological response of multicellular organisms caused by injuries, pathogens or irritants. An excessive inflammatory response can lead to tissue damage and various chronic diseases. Chronic inflammation is a common feature of many diseases, making the search for drugs to treat inflammation-related diseases urgent. Scutellarin, a natural flavonoid metabolite, is widely used in the treatment of various inflammation-related diseases for its anti-inflammatory, anti-oxidant and anti-cancer activities. Scutellarin can inhibit key inflammatory pathways (PI3K/Akt, MAPK, and NF-κB, etc.) and activate the anti-oxidant related pathways (Nrf2, ARE, ect.), thereby protecting tissues from inflammation and oxidative stress. Modern extraction technologies, such as microwave-assisted, ultrasound assisted, and supercritical fluid extraction, have been utilized to extract scutellarin from Scutellaria and Erigeron genera. These technologies improve efficiency and retain biological activity, making scutellarin suitable for large-scale production. Scutellarin has significant therapeutic effects in treating osteoarthritis, pulmonary fibrosis, kidney injury, and cardiovascular diseases. However, due to its low bioavailability and short half-life, its clinical application is limited. Researchers are exploring innovative formulations (β-cyclodextrin polymers, triglyceride mimetic active ingredients, and liposome precursors, etc.) to improve stability and absorption rates. Despite these challenges, the potential of scutellarin in anti-inflammatory, anti-oxidant, and anti-cancer applications remains enormous. By optimizing formulations, exploring combination therapies, and conducting in-depth mechanistic research, scutellarin can play an important role in treating various inflammatory diseases, providing patients with more and effective treatment options.Copyright © 2024 Zhou, Gu, Zhu, Zhu, Chen, Shi, Yang, Lu and Pang.