甘草查耳酮 A：对其药理学活性和分子机制的综述。
Licochalcone A: a review of its pharmacology activities and molecular mechanisms.
发表日期：2024
作者：
Meihua Liu, Yang Du, Dejiang Gao
来源：
Frontiers in Pharmacology
摘要：
甘草源自甘草的根，是一种重要的中药，具有解毒、健脾、补气的功效。甘草查尔酮 A (Lico A) 是甘草的重要成分，因其分子多功能性和受体结合亲和力而引起人们的兴趣。本文探讨了甘草A在多种疾病中的具体作用，为其特性提供新的见解，指导甘草的合理使用。通过CNKI、PubMed、Google Scholar等数据库，以“甘草应用”、“Lico A药理活性”等术语进行综合文献检索，收集Lico A药理活性和作用机制的相关研究。 Lico A 是甘草中代表性的查尔酮，针对抗癌和抗炎活性的特定机制。它还在转录后调控中发挥作用。本综述描述了 Lico A 抗癌和抗炎机制的异同，并得出其通过转录后机制对非编码 RNA 的影响值得进一步探索的结论。版权所有 © 2024 Liu、Du 和 Gau。
Licorice, derived from the root of Glycyrrhiza uralensis Fisch, is a key Traditional Chinese Medicine known for its detoxifying, spleen-nourishing, and qi-replenishing properties. Licochalcone A (Lico A), a significant component of licorice, has garnered interest due to its molecular versatility and receptor-binding affinity. This review explores the specific roles of Lico A in various diseases, providing new insights into its characteristics and guiding the rational use of licorice. Comprehensive literature searches using terms such as "licorice application" and "pharmacological activity of Lico A" were conducted across databases including CNKI, PubMed, and Google Scholar to gather relevant studies on Lico A's pharmacological activities and mechanisms. Lico A, a representative chalcone in licorice, targets specific mechanisms in anti-cancer and anti-inflammatory activities. It also plays a role in post-transcriptional regulation. This review delineates the similarities and differences in the anti-cancer and anti-inflammatory mechanisms of Lico A, concluding that its effects on non-coding RNA through post-transcriptional mechanisms deserve further exploration.Copyright © 2024 Liu, Du and Gao.