在传统肿瘤化疗领域，抗癌化疗（AC）已成为治疗癌症的有效策略。 AC 是实体和非实体癌症治疗的主要策略。其作用机制是阻断癌细胞中的 DNA 转录和细胞周期机制失调，从而激活死亡途径。然而，AC 对健康组织造成的毒性副作用带来了巨大的挑战。尽管氧化应激、线粒体损伤、炎症级联、自噬失调、细胞凋亡和某些异常信号传导都与 AC 毒性副作用的罪魁祸首有关，但其罪魁祸首尚不清楚。蜂蜜是一种天然蜂产品，具有显着的健康益处和药理特性。有趣的是，文献报道蜂蜜可能为脆弱的组织/器官提供保护机制，抵御 AC 毒性的副作用。因此，本综述深入探讨了蜂蜜作为 AC 毒性副作用缓解剂的前瞻性作用；它阐明了 AC 毒性的机制和蜂蜜的缓解分子机制。该综述致力于揭示蜂蜜协调其缓解作用的特定分子级联，其总体目标是完善其作为天然辅助产品的应用。蜂蜜补充剂通过抑制氧化应激、NF-κB 介导的炎症和 caspase 依赖性细胞凋亡级联来预防 AC 毒性。尽管需要加强机制研究，但蜂蜜是一种天然产品，可以减轻 AC 引起的各种毒性。

Within the domain of conventional oncochemotherapeutics, anticancer chemotherapy (AC) has emerged as a potent strategy for the treatment of cancers. AC is the mainstay strategy for solid and non-solid cancer treatment. Its mechanistic action targets the blockage of DNA transcription and the dysregulation of cell cycle machinery in cancer cells, leading to the activation of death pathways. However, the attendant side effect of toxicity inflicted by AC on healthy tissues presents a formidable challenge. The crucial culprit in the AC side effect of toxicity is unknown, although oxidative stress, mitochondrial impairment, inflammatory cascades, autophagy dysregulation, apoptosis, and certain aberrant signaling have been implicated. Honey is a natural bee product with significant health benefits and pharmacological properties. Interestingly, the literature reports that honey may proffer a protection mechanism for delicate tissue/organs against the side effect of toxicity from AC. Thus, this review delves into the prospective role of honey as an alleviator of the AC side effect of toxicity; it provides an elucidation of the mechanisms of AC toxicity and honey's molecular mechanisms of mitigation. The review endeavors to unravel the specific molecular cascades by which honey orchestrates its mitigating effects, with the overarching objective of refining its application as an adjuvant natural product. Honey supplementation prevents AC toxicity via the inhibition of oxidative stress, NF-κB-mediated inflammation, and caspase-dependent apoptosis cascades. Although there is a need for increased mechanistic studies, honey is a natural product that could mitigate the various toxicities induced by AC.