利用植物化学物质治疗神经母细胞瘤的潜力。
Harnessing the therapeutic potential of phytochemicals in neuroblastoma.
发表日期：2024 Aug 27
作者：
Seyed Sajad Ahmadi, Omid Bagherzadeh, Meysam Sargazi, Farnaz Kalantar, Mohammad Amin Elahi Najafi, Mohammad Mahdi Vahedi, Amir R Afshari, Amirhossein Sahebkar
来源：
BIOFACTORS
摘要：
神经母细胞瘤是脑外最常见的实体瘤，起源于未成熟的神经嵴细胞，约占所有儿科恶性肿瘤的 10%。神经母细胞瘤的治疗涉及多模式治疗，包括手术、放疗、化疗和免疫治疗。所有这些方法都受到可能严重的副作用、预后不良和复发风险高的限制。在寻求其他治疗方法的过程中，植物化学物质因其报道的抗肿瘤特性、安全性和多机制作用模式而引起了人们的关注。几项研究使用了植物源性生物活性化合物，如酚类和类黄酮，表明神经母细胞瘤涉及生物分子和信号转导途径的调节。我们回顾了最近的临床前和临床研究结果，证明了植物化学物质对神经母细胞瘤的影响，揭示了它们的分子作用机制和潜在的治疗应用。© 2024 国际生物化学和分子生物学联合会。
Neuroblastomas are the most common solid tumors outside of the brain that originate from immature neural crest cells, accounting for about 10% of all pediatric malignancies. The treatment for neuroblastomas involves a multimodal schedule, including surgery, radiation, chemotherapy, and immunotherapy. All these modalities are limited by side effects that might be severe, poor prognosis, and a high risk of recurrence. In the quest for additional therapeutic approaches, phytochemicals have attracted attention owing to their reported antitumor properties, safety, and multimechanistic mode of action. Several studies have used plant-derived bioactive compounds such as phenolics and flavonoids, suggesting modulation of biomolecules and signal transduction pathways involved in neuroblastoma. We reviewed the findings of recent preclinical and clinical studies demonstrating the effects of phytochemicals on neuroblastoma, shedding light on their molecular mechanism of action and potential therapeutic applications.© 2024 International Union of Biochemistry and Molecular Biology.