抗 GFAP 和抗 MOG 抗体的重叠综合征极为罕见。本回顾性研究报告了 8 例成人 GFAP-MOG 重叠综合征病例。我们回顾了 2019 年 1 月至 2023 年 9 月中山大学附属第三医院收治的 8 例 GFAP-MOG 重叠综合征成人患者的临床特征。此外，我们检索了文献，纳入了自 2018 年以来 PubMed 上出现这种重叠综合征的所有病例报告。主要的临床综合征是脑膜脑脊髓炎（5/8），其次是脑膜脑炎（2/8）和脊髓炎（1/8）。五名患者出现类似流感的前驱症状或腹泻。这些患者中没有发现肿瘤。关于脑 MRI，7 名患者出现 T2 加权/液体衰减反转恢复高信号，4 名患者出现软脑膜增强。然而，只有一名患者出现室周径向线性强化。此外，两名患者有较大的占位性病变。脊髓MRI显示4名患者出现T2高信号，其中3名患者存在纵向广泛病变。所有患者均接受免疫治疗，中位随访期为 18 个月（范围为 3-36 个月）。 3例患者随访期间出现复发，但末次随访时所有病例均恢复至mRS评分≤≤2。此外，我们还通过文献回顾的方式回顾了 14 例患有这种重叠综合征的病例（包括 7 名成人和 7 名儿童）。我们的研究结果为了解 GFAP-MOG 重叠综合征的临床特征和预后提供了数据。认识到这种重叠综合症将扩大我们的知识，从而更好地管理这些患者。© 2024。Springer-Verlag GmbH 德国，Springer Nature 旗下公司。

The overlapping syndrome of anti-GFAP and anti-MOG antibodies is extremely rare. This retrospective study reports 8 adult cases of the GFAP-MOG overlapping syndrome.We reviewed the clinical characteristics of 8 adult patients with the GFAP-MOG overlapping syndrome from Jan 2019 and Sep 2023 at the Third Affiliated Hospital, Sun Yat-sen University. Moreover, we searched the literature and included all case reports with this overlapping syndrome since 2018 on PubMed.The predominant clinical syndrome was meningoencephalomyelitis (5/8), followed by meningoencephalitis (2/8), and myelitis (1/8). Five patients had a flu-like prodromal symptom or diarrhea. No neoplasms were found in these patients. Regarding brain MRI, T2-weighted/fluid-attenuated inversion recovery hyperintensities were in 7 patients and leptomeningeal enhancement was in 4 patients. However, only one patient had periventricular radial linear enhancement. Besides, two patients had large space-occupying lesions. For spinal MRI, T2-hyperintensities were observed in 4 patients, in which 3 patients had longitudinally extensive lesions. All patients were treated with immunotherapy, the median follow-up period was 18 months (range, 3-36 months). Three patients presented relapses during the follow-up, but all cases recovered to mRS scores ≤ 2 at last follow-up. In addition, we also reviewed 14 cases (including 7 adults and 7 children) with this overlapping syndrome by literature review.Our findings provide data to understand the clinical features and prognosis of the GFAP-MOG overlapping syndrome. Recognizing this overlapping syndrome will expand our knowledge, allowing for better management of these patients.© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.