RNA m5C 修饰在中枢神经系统疾病中的作用。
The Role of RNA m5C Modification in Central Nervous System Diseases.
发表日期：2024 Aug
作者：
Peiyan Wu, Jiaxiang Gao, Guangming Lan, Yichao Wang
来源：
Alzheimers & Dementia
摘要：
随着RNA修饰研究的进展，5-甲基胞嘧啶(m5C)修饰的重要性越来越被人们所认识。 m5C 经过甲基转移酶 NOP2/Sun 结构域 (NSUN) 家族/DNA 甲基转移酶 (DNMT) 家族（写入器）的修饰，并被去甲基酶（擦除器）去除，包括 10-11 易位 (TET) 家族和 Alkb 同源物 1 (ALKBH1) 。此外，m5C 与 RNA 结合蛋白（阅读器）相互作用，例如 Y 盒结合蛋白 1 (YBX1) 和 Aly/REF 输出因子 (ALYREF)。在此结构框架上扩展，m5C修饰具有调节各种生理和病理过程的能力。近年来的研究表明，m5C在中枢神经系统中发挥着关键的调节作用，其失调可能与多种中枢神经系统疾病的发生和进展相关。在这篇综述中，我们总结了 m5C 成分的最新研究，并深入探讨了 m5C 参与中枢神经系统疾病（如阿尔茨海默病、脑肿瘤、癫痫和中风）的潜在机制。
As advances in RNA modification research progress, the significance of 5-methylcytosine (m5C) modification is being increasingly acknowledged. m5C undergoes modification by the methyltransferase NOP2/Sun domain (NSUN) family/DNA methyltransferase (DNMT) family (writer) and is removed by demethylases (eraser), including the ten-eleven translocation (TET) family and Alkb homolog 1 (ALKBH1). Moreover, m5C interacts with RNA-binding proteins (reader), such as Y-box-binding protein 1 (YBX1) and Aly/REF export factor (ALYREF). Expanding on this structural framework, m5C modification possesses the capacity to regulate various physiological and pathological processes. Recent studies indicate that m5C plays a pivotal regulatory role in the central nervous system, and its dysregulation may correlate with the onset and progression of various central nervous system diseases. In this review, we summarize recent research on m5C components and delve into the potential mechanisms of m5C involvement in central nervous system disorders, such as Alzheimer's disease, brain tumors, epilepsy, and stroke.