68Ga-Trivehexin PET/CT 在脑转移性非小细胞肺癌中的应用。
68Ga-Trivehexin PET/CT in Metastatic Non-Small Cell Lung Cancer to the Brain.
发表日期：2024 Aug 28
作者：
Fahad Marafi, Abdulredha A Esmail, Mahmoud A Alfeeli, Alyaa Sadeq
来源：
CLINICAL NUCLEAR MEDICINE
摘要：
在分子影像时代和渴望以非侵入性手段研究肿瘤组织微环境的时代，新的放射性示踪剂靶向分子的寻找和开发仍在继续。 αvβ6-整合素是一种异二聚体糖蛋白跨膜受体，其独特之处在于它仅在上皮细胞中表达。它在肺癌、乳腺癌和结肠癌等多种癌症中表达上调。它在癌症中发挥促进侵袭、抑制细胞凋亡、调节基质金属蛋白酶的表达以及激活TGF-β的作用。 αvβ6 的表达表明预后不良，有助于开发靶向治疗。 68Ga-Trivehexin 对该整合素的亲和力为 85%-88%。版权所有 © 2024 Wolters Kluwer Health, Inc. 保留所有权利。
In the era of molecular imaging and eager to study tumor tissues' microenvironment with noninvasive means, the search and development of new radiotracer targeted molecule continue. αvβ6-Integrin is a heterodimeric glycoprotein transmembrane receptor that is unique in that it is expressed exclusively in epithelial cells. It is upregulated in varieties of carcinomas such of the lung, breast, and colon. It plays a role in facilitating invasion, inhibiting apoptosis, regulating expression of matrix metalloproteases, and activating TGF-β in carcinoma. Expression of αvβ6 indicates poor prognosis and can help in development of targeted therapy. 68Ga-Trivehexin has affinity of 85%-88% of this integrin.Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.