本研究旨在进行系统评价和荟萃分析，以探讨木尘暴露与白血病之间的关系。目标包括综合现有证据，评估其质量，识别潜在的异质性来源，并得出有关木尘与白血病之间关联的结论。进行了系统的文献检索，以确定报告木尘与白血病之间关联的研究。采用乔安娜·布里格斯研究所的批判性评估工具来确保稳健的质量评估。使用随机效应模型的荟萃分析综合了低偏倚风险研究的证据。计算总体比值比 (OR) 和 95% 置信区间 (CI)。亚组分析探讨了异质性的潜在来源。荟萃分析包括对各种研究类型的全面回顾，其中包括 7 项研究，探讨木屑暴露与白血病风险之间的关联。分析显示存在统计学上显着的正相关，总体比值比 (OR) 为 1.56（95% CI：1.15-2.12）。这表明接触木屑的人患白血病的可能性是未接触木屑的人的 1.56 倍，95% 置信区间范围为 1.15 至 2.12，突显不同研究设计的风险显着升高。使用乔安娜·布里格斯研究所批判性评估工具进行的质量评估表明，所有纳入研究的偏倚风险较低，从而提高了所观察到的关联的可信度。进行亚组分析以探索研究中异质性的潜在来源。值得注意的是，基于研究年份的亚组分析显示出显着差异，I^2 值为 87%。这些结果的稳健性强调了解决木尘暴露作为职业危害的重要性，特别是在与木工和林业相关的行业。这项荟萃分析提供了强有力的证据，支持与木尘暴露相关的白血病风险增加，这意味着人们需要采取积极措施暴露在灰尘中。版权所有：© 2024 Soleimani 等人。这是一篇根据知识共享署名许可条款分发的开放获取文章，允许在任何媒体上不受限制地使用、分发和复制，前提是注明原始作者和来源。

This study aimed to perform a systematic review and meta-analysis to investigate the relationship between wood dust exposure and leukemia. The objectives included synthesizing available evidence, assessing its quality, identifying potential sources of heterogeneity, and drawing conclusions regarding the association between wood dust and leukemia.A systematic literature search was conducted to identify studies meeting that report on the association between wood dust and leukemia. The Joanna Briggs Institute Critical Appraisal tools were employed to ensure robust quality assessment. Meta-analysis, using random-effects models, synthesized evidence from studies with low risk of bias. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Subgroup analyses explored potential sources of heterogeneity.The meta-analysis included a comprehensive review of various study types, encompassing 7 studies that examined the association between wood dust exposure and leukemia risk. The analysis revealed a statistically significant positive association, with an overall odds ratio (OR) of 1.56 (95% CI: 1.15-2.12). This indicates that individuals exposed to wood dust are 1.56 times more likely to develop leukemia compared to those not exposed, with the 95% confidence interval ranging from 1.15 to 2.12, highlighting a substantial risk elevation across different study designs. Quality assessment using The Joanna Briggs Institute Critical Appraisal tools demonstrated a low risk of bias across all included studies, enhancing the credibility of the observed association. Subgroup analyses were conducted to explore potential sources of heterogeneity within the studies. Notably, subgroup analysis based on the year of the study revealed significant differences, as indicated by an I^2 value of 87%. The robustness of these results underscores the importance of addressing wood dust exposure as an occupational hazard, particularly in industries related to woodworking and forestry.This meta-analysis provides robust evidence supporting an increased risk of leukemia associated with wood dust exposure implying proactive measures in people exposed to dust.Copyright: © 2024 Soleimani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.