智力和发育障碍 (IDD) 人群的结直肠癌筛查存在差异。然而，该人群的手术结果仍有待研究。目前的工作旨在评估 IDD 与结直肠癌切除术后结果的关联。确定了 2011-2020 年全国住院患者样本中所有接受结直肠癌切除术的成人。我们开发了多变量线性和逻辑回归模型来检查 IDD 与危险因素以及死亡率、并发症、费用、住院时间 (LOS) 和非家庭出院等结局的关系。该研究因其回顾性而受到限制，未记录疾病分期或诊断时间。在 722,736 名接受结直肠癌切除术的患者中，2,846 名（0.39%）患有 IDD。与无 IDD 的患者相比，IDD 患者年龄较小，合并症负担也较高。 IDD 状态与非选择性入院几率增加（AOR 1.40 [95% CI 1.14-1.73]）和大容量中心治疗几率降低相关（AOR 0.64 [95% CI 0.51-0.81]）。此外，与神经正常患者相比，IDD 患者的 LOS（9 天 vs 6 天，p<0.001）和住院费用（23,500 美元 vs 19,800 美元，p<0.001）显着更高。风险调整后，IDD 与死亡率增加 2 倍（AOR 2.34 [95% CI 1.48-3.71]）、并发症增加 1.4 倍（AOR 1.41 [95% CI 1.15-1.74]）和 6.8 倍显着相关。非家庭出院人数增加了一倍（AOR 6.83 [95% CI 5.46-8.56]）。接受结直肠癌切除术的 IDD 患者非选择性入院、不良临床结果和资源使用的可能性增加。我们的研究结果强调需要更方便的筛查和以患者为中心的干预措施，以提高这一高危人群的手术护理质量。版权所有：© 2024 Ng 等人。这是一篇根据知识共享署名许可条款分发的开放获取文章，允许在任何媒体上不受限制地使用、分发和复制，前提是注明原始作者和来源。

Disparities in colorectal cancer screening have been documented among people with intellectual and developmental disabilities (IDD). However, surgical outcomes in this population have yet to be studied. The present work aimed to evaluate the association of IDD with outcomes following colorectal cancer resection.All adults undergoing resection for colorectal cancer in the 2011-2020 National Inpatient Sample were identified. Multivariable linear and logistic regression models were developed to examine the association of IDD with risk factors as well as outcomes including mortality, complications, costs, length of stay (LOS), and non-home discharge. The study is limited by its retrospective nature and did not capture disease staging or time of diagnosis.Among 722,736 patients undergoing colorectal cancer resection, 2,846 (0.39%) had IDD. Compared to patients without IDD, IDD patients were younger and had a higher burden of comorbidities. IDD status was associated with increased odds of non-elective admission (AOR 1.40 [95% CI 1.14-1.73]) and decreased odds of treatment at high-volume centers (AOR 0.64 [95% CI 0.51-0.81]). Furthermore, IDD patients experienced significantly greater LOS (9 vs 6 days, p<0.001) and hospitalization costs ($23,500 vs $19,800, p<0.001) relative to neurotypical patients. Upon risk adjustment, IDD was significantly associated with 2-fold increased odds of mortality (AOR 2.34 [95% CI 1.48-3.71]), 1.4-fold increase in complications (AOR 1.41 [95% CI 1.15-1.74]), and 6.8-fold increase in non-home discharge (AOR 6.83 [95% CI 5.46-8.56]).IDD patients undergoing colorectal cancer resection experience increased likelihood of non-elective admission, adverse clinical outcomes, and resource use. Our findings highlight the need for more accessible screening and patient-centered interventions to improve quality of surgical care for this at-risk population.Copyright: © 2024 Ng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.