ZG16 通过细菌代谢物影响肠道微生物群相关的肠道炎症和肺粘膜功能。
ZG16 impacts gut microbiota-associated intestinal inflammation and pulmonary mucosal function through bacterial metabolites.
发表日期：2024 Aug 26
作者：
Xinping Chen, Yixin Chen, Ying Zhang, Yonghuan Zhang, Yao Wang, Yingjia Li, Yaqi Sun, Guangxun Meng, Guiwen Yang, Hua Li
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY
摘要：
酶原颗粒 16 (ZG16) 是酶原颗粒中发现的一种分泌性糖蛋白，在结直肠炎症和癌症中也发挥着重要作用。在此，建立了ZG16基因敲除（ZG16-/-）小鼠系，我们发现ZG16缺失破坏了肠粘膜屏障和肠道微生物群，导致低水平炎症，并进一步促进溃疡性结肠炎和炎症的发展相关的结直肠癌。同时，对小鼠粪便的代谢组学分析表明，ZG16-/-和WT小鼠之间的代谢物存在显着差异，它们是宿主-微生物群通讯的重要介质，可能影响小鼠的肺部炎症。事实上，ZG16-/- 小鼠在支气管哮喘模型中表现出更严重的炎症。综上所述，结果表明，ZG16 在抑制实验动物结直肠和肺的炎症和调节免疫反应方面发挥着关键作用，这可能有助于更好地理解与 ZG16 相关的人类炎症性疾病的潜在机制。版权所有 © 2024 Elsevier B.V.版权所有。
Zymogen granule 16 (ZG16) is a secretory glycoprotein found in zymogen granules, which also plays an important role in colorectal inflammation and cancer. Herein, a ZG16 gene knock-out (ZG16-/-) mouse line was established and we found that ZG16 deletion damaged the intestinal mucosal barrier and gut microbiota, which resulted in low-level inflammation and further promoted the development of ulcerative colitis and inflammation-related colorectal cancer. Meanwhile, a metabolomics analysis on mouse feces showed that the metabolites significantly differed between ZG16-/- and WT mice, which were important mediators of host-microbiota communication and may impact the pulmonary inflammation of mice. Indeed, ZG16-/- mice showed more severe inflammation in a bronchial asthma model. Taken together, the results demonstrate that ZG16 plays a pivotal role in inhibiting inflammation and regulating immune responses in colorectum and lung of experimental animals, which may provide a better understanding of the underlying mechanism of human inflammatory diseases associated with ZG16.Copyright © 2024 Elsevier B.V. All rights reserved.