肺癌中的环状 RNA：对预防治疗耐药的影响。
Circular RNAs in lung cancer: implications for preventing therapeutic resistance.
发表日期：2024 Aug 26
作者：
Wenjuan Liu, Yawen Sun, Yanfei Huo, Long Zhang, Nasha Zhang, Ming Yang
来源：
EBioMedicine
摘要：
LC是最常见的恶性肿瘤之一，早期往往没有明显症状，当患者处于晚期且不再适合手术治疗时，就会导致晚期诊断。尽管可以进行辅助治疗，但随着时间的推移，患者常常会对这些治疗产生耐受，导致晚期 LC 患者的预后较差。近年来，环状RNA（circRNA）作为一种非编码RNA，在LC研究中受到了极大的关注。由于其独特的环状结构，circRNA在细胞内高度稳定。该综述系统总结了参与治疗抵抗的circRNA的表达、特征、生物学功能和分子调控机制，以及在LC早期诊断和基因靶向治疗中的潜在应用。版权所有©2024 The Authors。由 Elsevier B.V. 出版。保留所有权利。
LC is one of the most common malignant tumours that often presents with no distinct symptoms in the early stages, leading to late diagnoses when patients are at an advanced stage and no longer suitable for surgical treatment. Although adjuvant treatments are available, patients frequently develop tolerance to these treatments over time, resulting in poor prognoses for patients with advanced LC. Recently, circular RNAs (circRNAs), a type of non-coding RNA, have gained significant attention in LC research. Owing to their unique circular structure, circRNAs are highly stable within cells. This review systematically summarises the expression, characteristics, biological functions, and molecular regulatory mechanisms of circRNAs involved in therapy resistance as well as the potential applications in early diagnosis and gene targeting therapy in LC.Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.