癌症是由异常细胞不受控制的增殖引起的，长期以来一直是一个全球公共卫生问题。几十年来，天然产物已被证明是新型抗癌药物发现的重要来源。但它们的不稳定性、溶解度和生物利用度低、靶向性差阻碍了治疗效果。随着纳米技术的发展，纳米药物递送系统已成为提高药物生物利用度和增强疗效的有前途的策略。然而，构建合适的纳米载体仍然是一个重大挑战。多糖因其独特的理化性质、生物相容性和低免疫原性而被广泛用作纳米药物递送系统的载体材料。基于多糖的纳米药物递送系统具有高药物递送效率、受控药物释放和精确的肿瘤靶向性。本文综述了多糖纳米载体构建的影响因素以及多糖纳米载体在天然产物递送治疗各种癌症中的应用。它重点关注它们的体外和体内抗癌功效和机制。此外，该综述将多糖纳米载体与传统递送方法的能力和局限性进行了对比，强调了它们在实现靶向、降低毒性和优异的癌症治疗方式方面的潜力。最后，我们讨论了这一新兴领域当前的研究局限性和未来前景。版权所有 © 2024。由 Elsevier B.V. 出版。

Cancer, caused by uncontrolled proliferation of abnormal cells, has long been a global public health issue. For decades, natural products have been proven to be an essential source for novel anticancer drug discovery. But their instability, low solubility and bioavailability, poor targeting impede therapeutic efficacy. With the development of nanotechnology, nanomedicine delivery systems have emerged as promising strategies to improve bioavailability and enhance the therapeutic efficacy of drugs. However, constructing suitable nanocarrier is still a major challenge. Polysaccharides are extensively employed as carrier materials in nanomedicine delivery systems, owing to their unique physicochemical properties, biocompatibility and low immunogenicity. Polysaccharide-based nanomedicine delivery systems show high drug delivery efficiency, controlled drug release, and precise tumor targeting. This paper reviews influencing factors in the construction of polysaccharide-based nanocarriers and the application of polysaccharide-based nanocarriers for the delivery of natural products in treating various cancers. It focuses on their in vitro and in vivo anticancer efficacy and mechanisms. Furthermore, the review contrasts the capabilities and limitations of polysaccharide-based nanocarriers with traditional delivery methods, underlining their potential to enable targeted, reduced toxicity and excellent cancer treatment modalities. Finally, we discuss the current research limitations and future prospects in this emerging field.Copyright © 2024. Published by Elsevier B.V.