更糟糕的 Wilms 肿瘤结果与多个 T 细胞受体 CDR3-CMV 表位对的化学互补性相关。
Worse Wilms' Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs.
发表日期：2024
作者：
Kasey L Rigby, Michael J Diaz, Etienne C Gozlan, Dorottya B Kacsoh, Joanna J Song, Tabitha R Hudock, Andrea Chobrutskiy, Boris I Chobrutskiy, George Blanck
来源：
GENOMICS PROTEOMICS & BIOINFORMATICS
摘要：
肾母细胞瘤是小儿肾肿瘤，通常具有良好的预后和结果。病毒性疾病与肿瘤的发展有关，应被视为调节总体生存的一个因素。我们考虑了最近开发的适应性免疫受体、基因组学和生物信息学方法来评估巨细胞病毒 (CMV) 感染对维尔姆斯肿瘤的潜在影响。将来自 Wilms 肿瘤样本的 T 细胞受体 (TCR) 互补决定区 3 (CDR3) 氨基酸序列与已知的抗 CMV TCR CDR3 进行比较，该序列代表了抗 CMV TCR CDR3。 -CMV TCR CDR3 的结果更差。然后，针对肾母细胞瘤、TCR CDR3 和一系列 CMV 抗原的化学互补性评分方法进一步表明，与 CMV 抗原具有较高化学互补性的病例结果较差。总体而言，我们提出了一种评估 CMV 感染的潜在新方法并确定可以从治疗此类感染的疗法中受益的患者。版权所有 © 2024，国际抗癌研究所（George J. Delinasios 博士），保留所有权利。
Wilms' tumors are pediatric renal tumors that generally have a good prognosis and outcomes. Viral illnesses have been linked to development of neoplasms and should be considered as a factor that could modulate overall survival.We considered recently developed adaptive immune receptor, genomics and bioinformatics approaches to assess the potential impact of cytomegalovirus (CMV) infections in Wilms' tumor.T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences from Wilms' tumor specimens represented by the Therapeutically Applicable Research to Generate Effective Treatments dataset were compared with known anti-CMV TCR CDR3s, indicating that cases representing the anti-CMV TCR CDR3s had worse outcomes. Then, a chemical complementarity scoring approach for the Wilms' tumor, TCR CDR3s and a series of CMV antigens further indicated that cases representing a higher chemical complementarity to the CMV antigens had worse outcomes.Overall, we present a potentially novel method to assess CMV infections and identify patients who could benefit from therapies that address such infections.Copyright © 2024, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.