研究神经和神经胶质瘤干细胞静止的工具。
Tools to study neural and glioma stem cell quiescence.
发表日期：2024 Aug 26
作者：
Dana Friess, Stephanie Brauer, Anni Pöysti, Chandra Choudhury, Lachlan Harris
来源：
TRENDS IN NEUROSCIENCES
摘要：
静止是一种长期但可逆的细胞周期停滞状态，是大多数成体干细胞群的适应性特征。在大脑中，静止有助于保护成体神经干细胞免受压力并支持终生神经发生。然而不幸的是，进入静止或缓慢循环状态也是脑癌干细胞的恶性特征。在胶质母细胞瘤中，该过程已得到最好的表征，静止的胶质瘤干细胞优先在放化疗后存活，并且在治疗后重新激活以重新生长肿瘤并驱动复发。在这篇综述中，我们讨论了为研究神经干细胞静止而开发的体外和体内模型，以及如何使用这些工具加深生物学理解并开发针对静止神经胶质瘤干细胞的新疗法。版权所有 © 2024 Elsevier Ltd 。 版权所有。
Quiescence is a prolonged but reversible state of cell-cycle arrest that is an adaptive feature of most adult stem cell populations. In the brain, quiescence helps to protect adult neural stem cells from stress and supports lifelong neurogenesis. Unfortunately however, entry into a quiescent or a slow-cycling state is also a malignant feature of brain cancer stem cells. In glioblastoma, where the process has been best characterised, quiescent glioma stem cells preferentially survive chemoradiation, and after therapy, reactivate to regrow the tumour and drive recurrence. In this Review, we discuss the in vitro and in vivo models that have been developed for studying neural stem cell quiescence and how these tools may be used to deepen biological understanding and to develop novel therapies targeting quiescent glioma stem cells.Copyright © 2024 Elsevier Ltd. All rights reserved.