术后贫血与缺铁有关。我们研究了术后铁生物标志物在结直肠癌 (CRC) 中的预后价值。从 2769 名 CRC 患者术后单个时间点采集的血液中测量了铁蛋白、转铁蛋白、铁和转铁蛋白饱和度 (TS%)。使用具有风险比 (HR) 的 Cox 回归评估铁生物标志物与癌症特异性生存 (CSS) 和总生存 (OS) 之间的关联，并按术后采血时间（<1 个月/≥1 个月）进行分层中位随访 9.5 年后，52.6% 的患者死亡。对于术后 1 个月内评估的铁生物标志物，与正常 TS% 相比，较高的 TS% 与较短的 CSS 相关（HR [95% CI] = 2.36 [1.25-4.46]），并且较高的铁水平与较好的 OS 相关（上限与下限）。中位三分位数：HR [95% CI] = 0.79 [0.65-0.97]）。术后 1 个月以上进行评估时，铁蛋白升高与 CSS 较差相关（高与正常相比：HR [95% CI] = 1.44 [1.10-1.87]），而低 TS% 与较差 CSS 相关（低与正常相比） ：HR [95% CI] = 1.60 [1.24-2.06]）。 OS 也观察到类似但较弱的关联。术后 1 个月后血清铁蛋白和 TS% 的监测可能与可手术 CRC 患者的风险分层相关。未来的研究应该验证我们的发现。© 2024。作者。

Post-operative anaemia is linked to iron deficiency. We investigated the prognostic value of post-operative iron biomarkers in colorectal cancer (CRC).Ferritin, transferrin, iron, and transferrin saturation (TS%) were measured from blood collected at a single time-point post-surgery in 2769 CRC patients. Associations between iron biomarkers with cancer-specific survival (CSS) and overall survival (OS) were assessed using Cox regression with hazard ratios (HR), stratified by post-operative time of blood collection (<1-month/≥1-month).After a median follow-up of 9.5 years, 52.6% of patients had died. For iron biomarkers assessed <1-month post-surgery, higher compared to normal TS% was associated with shorter CSS (HR [95% CI] = 2.36 [1.25-4.46]), and higher iron levels with better OS (upper vs. median tertile: HR [95% CI] = 0.79 [0.65-0.97]). When assessed ≥1-month post-surgery, elevated ferritin was associated with poor CSS (high vs. normal: HR [95% CI] = 1.44 [1.10-1.87]), and low TS% with worse CSS (low vs. normal: HR [95% CI] = 1.60 [1.24-2.06]). Similar but weaker associations were observed for OS.Monitoring of serum ferritin and TS% beyond 1-month post-surgery may be relevant for risk stratification of patients with operable CRC. Future studies should validate our findings.© 2024. The Author(s).