评估基于血液的多癌症早期检测（MCED）测试的临床效用的试验正在进行中。如果要使用这些测试，了解公众对 MCED 筛查的态度至关重要。我们的目的是量化 MCED 筛查意图以及潜在的障碍和促进因素。年龄 50-77 岁的成年人 (n = 958) 完成了一项在线调查。主要结果是有意进行 MCED 筛查（如果提供）。评估了包括障碍和促进因素在内的心理变量。我们使用逻辑回归来探索社会人口统计与心理因素和意图之间的关联。93.8% 的参与者表示，如果提供的话，他们“肯定”或“可能”接受 MCED 筛查。意愿与之前的筛查参与和一般癌症态度显着相关，但与社会人口因素无关。如果参与者有更高的健康动机，并且认为血液测试有更大的好处，那么他们更有可能成为有意愿的人。如果参与者认为血液检测有更大的缺点、更多的实际障碍、更担心结果并且更关心阳性结果，那么他们不太可能成为有意向的人。MCED 筛查意向性很高。社会人口统计学差异的缺乏表明人们对此类筛查有公平的兴趣；然而，未来的研究应该考虑如何将意图转化为吸收。© 2024。作者。

Trials assessing the clinical utility of blood-based multi-cancer early detection (MCED) tests are underway. Understanding public attitudes towards MCED screening is essential if these tests are to be used. We aimed to quantify MCED screening intention and potential barriers and facilitators to uptake.Adults aged 50-77 (n = 958) completed an online survey. The primary outcome was intention to have MCED screening if offered. Psychological variables including barriers and facilitators were assessed. We used logistic regressions to explore associations between socio-demographics and psychological factors and intention.93.8% of participants said they would 'definitely' or 'probably' have MCED screening if offered. Intention was significantly associated with previous screening participation and general cancer attitudes but not with socio-demographic factors. Participants were more likely to be intenders if they had higher health motivation, and perceived greater benefits of blood tests. Participants were less likely to be intenders if they perceived greater disadvantages of blood tests, more practical barriers, were more worried about the outcome and more concerned about a positive result.MCED screening intention was high. The lack of socio-demographic variation suggests equitable interest in this type of screening; however, future research should consider how intention translates to uptake.© 2024. The Author(s).