了解胎盘发育与癌症之间的交叉点：肿瘤抑制因子 BAP1 的教训。
Understanding the intersection between placental development and cancer: Lessons from the tumor suppressor BAP1.
发表日期：2024 Aug 27
作者：
Paula Doria-Borrell, Vicente Pérez-García
来源：
Cell Death & Disease
摘要：
胎盘是哺乳动物生殖的关键器官，它允许母亲和发育中的胎儿之间进行营养交换和激素信号传导。了解其分子复杂性对于破译正常胚胎发育和肿瘤发生等病理状况至关重要。在这里，我们探讨肿瘤抑制因子 BRCA1 相关蛋白 1 (BAP1) 在癌症和胎盘形成中的多方面作用。 BAP1 最初因其肿瘤抑制特性而被认可，现已成为肿瘤发生和胎盘发育交叉点的关键调节因子。 BAP1 影响重要的细胞过程，例如细胞死亡、增殖、代谢和对缺氧条件的反应。 通过整合肿瘤和发育生物学的见解，我们阐明了 BAP1 精心策划的复杂分子途径。这一观点强调了 BAP1 对癌症和胎盘发育的重大影响，并提出了可以改善妊娠疾病和癌症结果的新治疗策略。© 2024。作者。
The placenta, a pivotal organ in mammalian reproduction, allows nutrient exchange and hormonal signaling between the mother and the developing fetus. Understanding its molecular intricacies is essential for deciphering normal embryonic development and pathological conditions such as tumorigenesis. Here, we explore the multifaceted role of the tumor suppressor BRCA1-associated protein 1 (BAP1) in cancer and placentation. Initially recognized for its tumor-suppressive properties, BAP1 has emerged as a key regulator at the intersection of tumorigenesis and placental development. BAP1 influences crucial cellular processes such as cell death, proliferation, metabolism, and response to hypoxic conditions. By integrating insights from tumor and developmental biology, we illuminate the complex molecular pathways orchestrated by BAP1. This perspective highlights BAP1's significant impact on both cancer and placental development, and suggests novel therapeutic strategies that could improve outcomes for pregnancy disorders and cancer.© 2024. The Author(s).