决策后悔是一种新出现的患者报告结果。本研究的目的是评估接受细胞减灭术和腹腔热灌注化疗 (CRS-HIPEC) 的阑尾癌 (AC) 患者后悔的发生率。通过阑尾癌和腹膜假粘液瘤 (ACPMP) 向患者分发匿名调查）研究基金会。采用决策后悔量表（DRS），DRS > 25 表示后悔。对后悔或不后悔 (NO-REG) 手术的患者之间的患者人口统计、肿瘤特征、术后结果、症状 (FACT-C) 和 PROMIS-29 生活质量 (QoL) 评分进行比较。总共 122 名患者进行了分析。绝大多数人对接受 CRS-HIPEC 并不后悔（85.2%）； 18名患者表示遗憾（14.8%）。后悔程度较高的患者具有：收入 ≤ 74,062 美元（72.2% vs 44.2% NO-REG；p = 0.028），手术后 30 天内发生主要并发症（55.6% vs 15.4% NO-REG；p < 0.001），住院时间 > 30 天住院治疗（38.9% vs 4.8% NO-REG；p < 0.001）、新造口术（27.8% vs 7.7% NO-REG；p = 0.03）、>1 CRS-HIPEC 手术（56.3% vs 12.6% NO-REG； p < 0.001）。 FACT-C 评分较差的患者后悔程度更高 (p < 0.001)。后悔的患者的 PROMIS-29 生活质量评分普遍较差。多变量分析表明，住院时间 > 30 天、新的造口术和较差的胃肠道症状评分与后悔显着相关。大多数接受 CRS-HIPEC 的 AC 患者并不后悔接受该手术。收入较低、术后并发症、造口术、接受 > 1 次手术以及更严重的长期胃肠道症状与后悔增加有关。有针对性的围手术期心理支持和症状管理可能有助于减轻遗憾。© 2024。外科肿瘤学会。

Decision regret is an emerging patient reported outcome. The aim of this study was to assess the incidence of regret in patients with appendiceal cancer (AC) who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC).An anonymous survey was distributed to patients through the Appendix Cancer and Pseudomyxoma Peritonei (ACPMP) Research Foundation. The Decision Regret Scale (DRS) was employed, with DRS > 25 signifying regret. Patient demographics, tumor characteristics, postoperative outcomes, symptoms (FACT-C), and PROMIS-29 quality of life (QoL) scores were compared between patients who regretted or did not regret (NO-REG) the procedure.A total of 122 patients were analyzed. The vast majority had no regret about undergoing CRS-HIPEC (85.2%); 18 patients expressed regret (14.8%). Patients with higher regret had: income ≤ $74,062 (72.2% vs 44.2% NO-REG; p = 0.028), major complications within 30 days of surgery (55.6% vs 15.4% NO-REG; p < 0.001), > 30 days hospital stay (38.9% vs 4.8% NO-REG; p < 0.001), a new ostomy (27.8% vs 7.7% NO-REG; p = 0.03), >1 CRS-HIPEC procedure (56.3% vs 12.6% NO-REG; p < 0.001). Patients with worse FACT-C scores had more regret (p < 0.001). PROMIS-29 QOL scores were universally worse in patients with regret. Multivariable analysis demonstrated > 30 days in the hospital, new ostomy and worse gastrointestinal symptom scores were significantly associated with regret.The majority of patients with AC undergoing CRS-HIPEC do not regret undergoing the procedure. Lower income, postoperative complications, an ostomy, undergoing > 1 procedure, and with worse long-term gastrointestinal symptoms were associated with increased regret. Targeted perioperative psychological support and symptom management may assist to ameliorate regret.© 2024. Society of Surgical Oncology.