本研究旨在探讨初诊急性早幼粒细胞白血病（APL）患者的临床特征及早期死亡相关因素分析。本回顾性研究纳入2010年1月至2022年8月期间就诊于我院并诊断为APL的患者。第一次与 APL 合作。我们分析了他们的临床和实验室特征，并分析了与早期死亡相关的因素。共收集了269例初次诊断为APL的患者。男女比例为6：5，中位年龄为42岁（范围7-80岁）。在初次诊断为 APL 的患者中，有 34 人早期死亡，早期死亡率为 13%。从诊断到死亡的中位时间为 8.5 天（范围 3-24 天）。使用逻辑回归模型对早亡患者和非早亡患者的临床特征进行比较分析，结果显示年龄、初诊时白细胞计数（WBC）和凝血酶原时间（PT）延长是独立风险原发性APL患者早期死亡的影响因素（P<<0.05）。比较早期死亡组与非早期死亡组住院期间的临床特征，发现早期死亡患者住院期间白细胞日均值显着高于非早期死亡患者（P < 0.001）。相反，早期死亡患者的血小板计数（PLT）日均值显着低于未死亡患者（P<0.001）。此外，早亡患者和早亡患者住院期间平均每日PLT输注量（P < 0.05）、纤维蛋白原（Fib）（P < 0.05）和新鲜冰冻血浆（FFP）（P < 0.05）差异有统计学意义。那些没有的人。具体而言，早期死亡组的 PLT 和 FFP 每日平均输注量显着高于非早期死亡组。 34 名早期死亡患者中，有 25 名（74%）的直接死亡原因是脑出血。其余死亡原因包括感染5例（15%），均为严重肺部感染，其中合并分化综合征2例，以及初诊时放弃治疗4例（11%）。 APL、年龄、初诊时WBC、PT延长时间被确定为早期死亡的独立危险因素（P<0.05）。住院期间有关 WBC 和 PLT 的实验室检查结果，以及住院期间输注的 PLT、Fib 和 FFP 也具有统计学意义。脑出血被发现是原发性 APL 患者早期死亡的主要原因。© 2024。作者。

The objective of this study was to investigate the clinical characteristics and analysis of related factors associated with early death in newly diagnosed patients with acute promyelocytic leukemia (APL).This retrospective study included patients who visited our hospital between January 2010 and August 2022 and were diagnosed with APL for the first time. We analyzed their clinical and laboratory characteristics and analysis of related factors associated with early death.A total of 269 patients with a primary diagnosis of APL were collected. The male to female ratio was 6:5, and the median age was 42 years (range 7-80). Among patients with initial APL diagnosis, there were 34 early deaths, resulting in an early mortality rate of 13%. The median time from diagnosis to death was 8.5 days (range 3-24). Comparative analysis of the clinical characteristics between patients who died early and those who did not, using a logistic regression model, revealed that age, white blood cell count (WBC) at initial diagnosis, and prolongation time of prothrombin time (PT) were independent risk factors for early death in patients with primary APL (P < 0.05). Comparing the clinical characteristics during hospitalization between the early death group and the non-early death group, it was observed that the daily mean of WBC during hospitalization was significantly higher in patients who died early than in those who did not (P < 0.001). Conversely, the daily mean of platelet count (PLT) was significantly lower in patients who died early compared to those who did not (P < 0.001). Furthermore, statistically significant differences were found in the mean daily infusion of PLT (P < 0.05), fibrinogen (Fib) (P < 0.05), and fresh frozen plasma (FFP) (P < 0.05) during hospitalization between patients who died early and those who did not. Specifically, the mean daily infusion of PLT and FFP was significantly higher in the early-death group than in the non-early-death group. Cerebral hemorrhage was identified as the immediate cause of death in 25 out of the 34 early-death patients (74%). The remaining causes of death included infection in 5 cases (15%), all of which were severe pulmonary infections, including 2 cases of combined differentiation syndrome, and abandonment of treatment in 4 patients (11%) at initial diagnosis.In patients with primary APL, age, WBC at initial diagnosis, and PT prolongation time were identified as independent risk factors for early death (P < 0.05). Laboratory findings regarding WBC and PLT during hospitalization, as well as the infusion of PLT, Fib, and FFP during hospitalization, were also statistically significant. Cerebral hemorrhage was found to be the main cause of early death in patients with primary APL.© 2024. The Author(s).