癌症耐药性中非编码RNA对铁死亡的表观遗传修饰。
Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance.
发表日期：2024 Aug 27
作者：
Hongquan Wang, Joshua S Fleishman, Sihang Cheng, Weixue Wang, Fan Wu, Yumin Wang, Yu Wang
来源：
Epigenetics & Chromatin
摘要：
耐药性的发展仍然是癌症治疗的主要挑战。铁死亡是一种独特的受调节细胞死亡类型，在抑制肿瘤生长方面发挥着关键作用，为治疗化疗耐药性提供了新的机会。越来越多的研究表明，非编码 RNA (ncRNA) 的表观遗传修饰可以决定癌细胞对铁死亡的脆弱性。在这篇综述中，我们首先总结了化疗耐药性在癌症生长/发展中的作用。然后，我们总结了铁死亡的核心分子机制、其上游表观遗传调控及其下游对化疗耐药的影响。最后，我们回顾了理解 ncRNA 如何调节铁死亡并由此调节化疗耐药性的最新进展。本综述旨在增强对 ncRNA 介导的调节铁死亡的表观遗传调控机制的一般理解，强调 ncRNA-铁死亡轴作为克服化疗耐药性的关键药物靶标。© 2024。作者。
The development of drug resistance remains a major challenge in cancer treatment. Ferroptosis, a unique type of regulated cell death, plays a pivotal role in inhibiting tumour growth, presenting new opportunities in treating chemotherapeutic resistance. Accumulating studies indicate that epigenetic modifications by non-coding RNAs (ncRNA) can determine cancer cell vulnerability to ferroptosis. In this review, we first summarize the role of chemotherapeutic resistance in cancer growth/development. Then, we summarize the core molecular mechanisms of ferroptosis, its upstream epigenetic regulation, and its downstream effects on chemotherapeutic resistance. Finally, we review recent advances in understanding how ncRNAs regulate ferroptosis and from such modulate chemotherapeutic resistance. This review aims to enhance general understanding of the ncRNA-mediated epigenetic regulatory mechanisms which modulate ferroptosis, highlighting the ncRNA-ferroptosis axis as a key druggable target in overcoming chemotherapeutic resistance.© 2024. The Author(s).