类器官作为原发性肝癌研究的一个有前途的工具：全面综述。
Organoid as a promising tool for primary liver cancer research: a comprehensive review.
发表日期：2024 Aug 27
作者：
Xuekai Hu, Jiayun Wei, Pinyan Liu, Qiuxia Zheng, Yue Zhang, Qichen Zhang, Jia Yao, Jingman Ni
来源：
Disease Models & Mechanisms
摘要：
原发性肝癌（PLC）是世界范围内最常见的恶性胃肠道肿瘤之一。受限于肝移植供体短缺和肿瘤的异质性，肝癌患者缺乏有效的治疗方案，导致病情快速进展和转移。目前，PLC的临床前模型与临床现实存在差距，并且对疾病进展的反应和药物治疗的有效性受到限制。类器官是体外三维培养的临床前模型，具有高度异质性，保留原发肿瘤的组织形态学和基因组特征。肝癌类器官已广泛应用于药物筛选、新靶点发现、精准医疗等领域；因此是研究 PLC 的一个有前途的工具。在这里，我们总结了肝癌类器官的研究进展及其作为疾病模型的潜在应用。这篇综述全面介绍了这一新兴技术，并为研究人员在精准医学领域探索提供了新思路。© 2024。作者。
Primary liver cancer (PLC) is one of the most common malignant gastrointestinal tumors worldwide. Limited by the shortage of liver transplantation donors and the heterogeneity of tumors, patients with liver cancer lack effective treatment options, which leads to rapid progression and metastasis. Currently, preclinical models of PLC fall short of clinical reality and are limited in their response to disease progression and the effectiveness of drug therapy. Organoids are in vitro three-dimensional cultured preclinical models with a high degree of heterogeneity that preserve the histomorphological and genomic features of primary tumors. Liver cancer organoids have been widely used for drug screening, new target discovery, and precision medicine; thus representing a promising tool to study PLC. Here, we summarize the progress of research on liver cancer organoids and their potential application as disease models. This review provides a comprehensive introduction to this emerging technology and offers new ideas for researchers to explore in the field of precision medicine.© 2024. The Author(s).