探讨高白细胞急性白血病（HAL）患者使用动脉血氧饱和度（SaO2）和指尖脉搏血氧饱和度（SpO2）进行血氧检测时哪个指标更有优势。在这项前瞻性研究中，SaO2和SpO2之间的差异为18分析HAL患者（观察组）和14例患者（对照组），以及差异与白细胞（WBC）计数的关系。观察组SaO2低于SpO2（P <0.05），SpO2 -SaO2 差异与 WBC 计数呈正相关 (r =0.47)。然而，对照组SaO2和SpO2之间没有统计学差异。观察组采集动脉血后随着检测时间的延长,SaO2、PO2呈下降趋势,但差异无统计学意义。对照组SaO2和PO2无下降趋势。HAL患者存在SaO2低于SpO2的现象，即假性低氧血症，这种现象可能是白血病细胞体外耗氧过多造成的。床边实时监测，无创，是检测HAL患者血氧状况的较好方法。

To investigate which indicator is more advantageous when using arterial oxygen saturation (SaO2) and fingertip pulse oxygen saturation (SpO2) for blood oxygen detection in patients with hyperleukocytic acute leukemia (HAL).In this prospective research, the difference between SaO2 and SpO2 of 18 HAL patients (observation group) and 14 patients (control group), as well as the relationship between the difference and white blood cell (WBC) counts were analyzed.SaO2 was lower than SpO2 in the observation group (P <0.05), and SpO2-SaO2 difference was positively correlated with WBC counts (r =0.47). However, there was no statistical difference between SaO2 and SpO2 in the control group. SaO2 and PO2 showed a downward trend with the prolongation of detection time after arterial blood was collected in the observation group, but there was no statistical difference. There was no downward trend of SaO2 and PO2 in the control group.HAL patients have a phenomenon where SaO2 is lower than SpO2, that is pseudohypoxemia, and this phenomenon may be caused by excessive consumption of oxygen by the leukemia cells in vitro SpO2 can be monitored bedside in real time and is non-invasive, it is a better way to detect the blood oxygen status of HAL patients.