急性白血病并发肺部感染的诊治研究进展--综述
[Research Progress in Diagnosis and Treatment of Acute Leukemia Complicated with Pulmonary Infection--Review].
发表日期：2024 Aug
作者：
Hao Ji, Xiao-Sui Ling, Zeng-Zheng Li, Tong-Hua Yang
来源：
Cellular & Molecular Immunology
摘要：
急性白血病是一组死亡率较高的侵袭性恶性肿瘤。由于疾病本身和放化疗导致的功能性免疫细胞减少，使患者容易发生合并感染，其中肺部感染是主要的死亡原因。急性白血病合并肺部感染患者的早期准确诊断和适当治疗可以防止感染扩散，从而减少败血症、呼吸衰竭和多器官衰竭等严重并发症。然而，急性白血病患者肺部感染的诊断和治疗仍存在临床困难。因此，本文对目前急性白血病患者肺部细菌、真菌和病毒感染的诊治研究进展进行简要总结。
Acute leukaemia is a group of aggressive malignancies with a high mortality rate. The reduction in functional immune cells due to the disease itself and radiotherapy/chemotherapy makes the patients susceptible to co-infections, of which pulmonary infection is a major cause of death. Early accurate diagnosis and appropriate treatment may prevent the spread of infection in patients with acute leukaemia complicated with pulmonary infection, thus reduce serious complications such as sepsis, respiratory failure and multi-organ failure. However, there are still clinical difficulties in the diagnosis and treatment of pulmonary infections in acute leukemia patients. Therefore, the current research advances in the diagnosis and treatment of bacterial, fungal and viral infections in the lungs of patients with acute leukemia were briefly summarized in this review.