Mn-ZIF 纳米酶通过产生羟基自由基以及逆转肿瘤微环境来杀死肿瘤。
Mn-ZIF nanozymes kill tumors by generating hydroxyl radical as well as reversing the tumor microenvironment.
发表日期：2024
作者：
Jiyu Han, Hairong Ma, Songtao Ai, Daqian Wan
来源：
Frontiers in Pharmacology
摘要：
肿瘤组织以其独特的高过氧化氢 (H2O2) 微环境而闻名。如何利用这种肿瘤微环境来杀死肿瘤细胞是一个问题。在这项研究中，构建了锰掺杂的金属有机骨架（Mn-ZIF）。它具有良好的过氧化物酶（POD）活性，可将肿瘤定位的H2O2氧化成羟基自由基（·OH），具有直接杀伤肿瘤细胞的能力。更令人惊讶的是，在体内实验中研究人员不仅观察到了Mn-ZIF的杀伤肿瘤作用，还发现它改变了肿瘤区域巨噬细胞表型。巨噬细胞向 M1 亚型的极化增加。这表明Mn-ZIF的杀伤作用不仅来自于其POD活性，还可以调节肿瘤区域的免疫微环境。总之，Mn-ZIF的制备为肿瘤综合治疗提供了新途径。版权所有©2024韩马艾万。
Tumor tissues are well known for their unique high hydrogen peroxide (H2O2) microenvironment. How to exploit this tumor microenvironment for tumor cell killing is a question. In this study, a Mn-doped metal-organic framework (Mn-ZIF) was constructed. It possesses good peroxidase (POD) activity, which can oxidize tumor-localized H2O2 into hydroxyl radicals (·OH), that possesses the ability to directly kill tumor cells. More surprisingly, in vivo experiments the researchers not only observed the tumor-killing effect of Mn-ZIF, but also found it changes in macrophage phenotype in the tumor region. There was an increase in macrophage polarization towards the M1 subtype. This suggests that the tumor-killing effect of Mn-ZIF not only comes from its POD activity, but also regulates the immune microenvironment in the tumor region. In conclusion, the preparation of Mn-ZIF provides a new way for comprehensive tumor therapy.Copyright © 2024 Han, Ma, Ai and Wan.