人体是一个复杂的整体，一个器官的破坏可能会导致器官网络其他部分的功能障碍。面神经作为第七脑神经，起源于脑干，控制面部表情肌肉，在脑体交流中发挥着至关重要的作用。这种脆弱的神经可能会因创伤、炎症、肿瘤和先天性疾病而受损，通常会损害面部表情。干细胞由于其多向分化潜力而在修复周围神经损伤方面受到广泛关注。此外，各种生物材料已用于组织工程中的再生和修复。然而，干细胞和生物材料在治疗面神经损伤方面的治疗潜力还需要进一步探索。在这篇综述中，我们总结了干细胞和生物材料在受损面神经再生和修复中的作用，为大脑和面部表情肌肉之间的体脑串扰的恢复和重建提供理论基础。版权所有©2024。已发表由爱思唯尔公司

The human body is a complex, integral whole, and disruptions in one organ can lead to dysfunctions in other parts of the organ network. The facial nerve, as the seventh cranial nerve, arises from the brainstem, controls facial expression muscles and plays a crucial role in brain-body communication. This vulnerable nerve can be damaged by trauma, inflammation, tumors, and congenital diseases, often impairing facial expression. Stem cells have gained significant attention for repairing peripheral nerve injuries due to their multidirectional differentiation potential. Additionally, various biomaterials have been used in tissue engineering for regeneration and repair. However, the therapeutic potential of stem cells and biomaterials in treating facial nerve injuries requires further exploration. In this review, we summarize the roles of stem cells and biomaterials in the regeneration and repair of damaged facial nerves, providing a theoretical basis for the recovery and reconstruction of body-brain crosstalk between the brain and facial expression muscles.Copyright © 2024. Published by Elsevier Inc.