乳铁蛋白 (Lf) 是转铁蛋白家族中的一种多功能蛋白质。它涉及许多生理功能，包括铁吸收和免疫反应的调节。在病理生理条件下还具有抗菌、抗病毒、抗炎、抗癌和抗氧化能力。哺乳动物乳铁蛋白受体 (LfR) 在介导 Lf 的多种功能中发挥着关键作用。研究表明，Lf/LfR在帕金森病的大脑中异常表达，Lf和LfR的过度表达导致大脑中铁的过度积累，被认为是帕金森病多巴胺能神经元变性的最初原因之一。帕金森病。另一方面，近期多项研究报道Lf/LfR对帕金森病具有显着的神经保护作用。换句话说，Lf/LfR 对帕金森病同时具有神经退行性和神经保护作用，这似乎是矛盾的。本文重点介绍了Lf/LfR在帕金森病中神经退行性和神经保护作用的可能机制的最新进展，并讨论了为什么Lf/LfR在帕金森病的发展中具有看似矛盾的作用。根据目前获得的证据，我们认为Lf/LfR对帕金森病具有神经保护作用，而对于Lf/LfR的过度表达是否是帕金森病发生的原因，目前证据不足，需要进一步研究.版权所有 © 2024。由 Elsevier B.V. 出版

Lactoferrin (Lf) is a multifunctional protein in the transferrin family. It is involved in many physiological functions, including the regulation of iron absorption and immune response. It also has antibacterial, antiviral, anti-inflammatory, anticancer and antioxidant capabilities under pathophysiological conditions. The mammalian lactoferrin receptor (LfR) plays a key role in mediating multiple functions of Lf. Studies have shown that Lf/LfR is abnormally expressed in the brain of Parkinson's disease, and the excessive accumulation of iron in the brain caused by the overexpression of Lf and LfR is considered to be one of the initial causes of the degeneration of dopaminergic neurons in Parkinson's disease. On the other hand, a number of recent studies have reported that Lf/LfR has a significant neuroprotective effect on Parkinson's disease. In other words, it seems paradoxical that Lf/LfR has both neurodegenerative and neuroprotective effects in Parkinson's disease. This article focuses on recent advances in the possible mechanisms of the neurodegenerative and neuroprotective effects of Lf/LfR in Parkinson's disease and discusses why Lf/LfR has a seemingly contradictory role in the development of Parkinson's disease. Based on the evidence obtained so far, we believed that Lf/LfR has a neuroprotective effect on Parkinson's disease, while as to whether the overexpressed Lf/LfR is the cause of the development of Parkinson's disease, the current evidence is insufficient and further investigation needed.Copyright © 2024. Published by Elsevier B.V.