胃肠癌是一个全球性的健康挑战，因为其患病率急剧上升，并且是癌症相关死亡的主要原因。越来越多的证据表明肠道微生物衍生的代谢物在胃肠道癌症的进展和治疗中发挥着重要作用。微生物代谢物是由肠道微生物群产生的，肠道微生物群利用外在膳食成分和内在宿主产生的化合物。与此同时，某些类别的代谢物，如短链脂肪酸、胆汁酸、色氨酸和吲哚衍生物，与胃肠道恶性肿瘤有关。本综述介绍了微生物代谢物的主要类别及其对各种胃肠道癌症（包括结直肠癌、胃癌和肝细胞癌）的影响。微生物代谢物作为胃肠道癌症早期诊断和预后预测生物标志物的应用也得到了探索。此外，还进一步评估了针对胃肠道癌症的微生物代谢物策略的治疗潜力。版权所有 © 2024 作者。由爱思唯尔有限公司出版。保留所有权利。

Gastrointestinal cancer is a worldwide health challenge due to its dramatically increasing prevalence and as a leading cause of cancer-related mortality. Increasing evidence has illustrated the vital role of gut microbes-derived metabolites in gastrointestinal cancer progression and treatment. Microbial metabolites are produced by the gut microbiota that utilizes both extrinsic dietary components and intrinsic host-generated compounds. Meanwhile, certain categories of metabolites such as short-chain fatty acids, bile acids, tryptophan, and indole derivatives, are linked to gastrointestinal malignancy. In this review, the major classes of microbial metabolites and their impacts on various gastrointestinal cancers including colorectal cancer, gastric cancer, and hepatocellular carcinoma, have been introduced. The application of microbial metabolites as predictive biomarkers for early diagnosis and prognosis of gastrointestinal cancer has also been explored. In addition, therapeutic potential of strategies that target microbial metabolites against gastrointestinal cancer is further evaluated.Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.