AMP 激活蛋白激酶 (AMPK) 是一种蛋白激酶，在响应各种生理应激（包括葡萄糖缺乏、缺氧和缺血）时发挥多种作用。作为一种具有多效性功能的激酶，它在肿瘤进展中发挥着复杂的作用，表现出促肿瘤和抑制肿瘤的活性。一方面，AMPK增强癌细胞增殖和存活，促进癌症转移，损害抗肿瘤免疫。另一方面，AMPK 抑制癌细胞生长和存活，并以环境依赖性方式刺激免疫反应。除了这些功能之外，AMPK 在协调衰老和衰老相关疾病（包括心血管疾病 (CVD)、骨关节炎 (OA) 和糖尿病）方面发挥着关键作用。在这篇综述文章中，我们根据 AMPK 通路的致癌和抑癌作用总结了其功能，并强调了 AMPK 通路在调节细胞衰老中的重要性。我们还强调了 AMPK 的各种信号通路、激活剂和抑制剂在作为抗癌和抗衰老疗法的治疗策略中的重要作用。版权所有 © 2024 Elsevier Ltd. 保留所有权利。

AMP-activated protein kinase (AMPK) is a protein kinase that plays versatile roles in response to a variety of physiological stresses, including glucose deprivation, hypoxia, and ischemia. As a kinase with pleiotropic functions, it plays a complex role in tumor progression, exhibiting both tumor-promoting and tumor-suppressing activities. On one hand, AMPK enhances cancer cell proliferation and survival, promotes cancer metastasis, and impairs anti-tumor immunity. On the other hand, AMPK inhibits cancer cell growth and survival and stimulates immune responses in a context-dependent manner. Apart from these functions, AMPK plays a key role in orchestrating aging and aging-related disorders, including cardiovascular diseases (CVD), Osteoarthritis (OA), and Diabetes. In this review article, we summarized the functions of AMPK pathway based on its oncogenic and tumor-suppressive roles and highlighted the importance of AMPK pathway in regulating cellular aging. We also spotlighted the significant role of various signaling pathways, activators, and inhibitors of AMPK in serving as therapeutic strategies for anti-cancer and anti-aging therapy.Copyright © 2024 Elsevier Ltd. All rights reserved.