目的 探讨早期乳腺癌患者术前乳腺 MRI 特征、腋窝淋巴结负荷 (ANB) 和无病生存 (DFS) 之间的潜在关联。我们回顾性分析了 297 例早期乳腺癌 (cT1-2N0M0) 患者。 ）于2016年12月至2018年12月期间接受术前MRI检查。根据术后病理确定的阳性腋窝淋巴结（LN）数量，将患者分为高淋巴结负荷（HNB；≥3个阳性LN）和非HNB（ <3 个阳性 LN) 组。进行单变量和多变量逻辑回归分析以确定与 ANB 相关的独立危险因素。使用受试者工作特征（ROC）曲线和曲线下面积（AUC）评估预测功效。进行单变量和多变量 Cox 比例风险回归分析以确定与 DFS 相关的术前特征。我们分别纳入了 HNB 组和非 HNB 组的 47 名患者和 250 名患者。多变量逻辑回归分析显示，多灶性/多中心性（调整后的比值比 [OR] = 3.905，95% 置信区间 [CI]：1.685-9.051，P = 0.001）和瘤周水肿（调整后的 OR = 3.734，95% CI：1.644- 8.479, P = 0.002) 是 HNB 的独立危险因素。瘤周水肿和多灶性/多中心性相结合预测 HNB 的 AUC 为 0.760 (95% CI: 0.707-0.807)，敏感性和特异性分别为 83.0% 和 63.2%。在中位随访45个月（范围5-61个月）期间，观察到26例（8.75%）乳腺癌复发。多变量Cox比例风险回归分析表明，年龄较小（调整后的风险比[HR] = 3.166，95％CI：1.200-8.352，P = 0.021），较大的肿瘤尺寸（调整后的HR = 4.370，95％CI：1.671-11.428， P = 0.002）和多焦/多中心（调整后 HR = 5.059，95% CI：2.166-11.818，P < 0.001）与 DFS 独立相关。术前乳腺 MRI 特征可能与早期患者的 ANB 和 DFS 相关。乳腺癌。版权所有 © 2024 韩国放射学会。

To investigate the potential association among preoperative breast MRI features, axillary nodal burden (ANB), and disease-free survival (DFS) in patients with early-stage breast cancer.We retrospectively reviewed 297 patients with early-stage breast cancer (cT1-2N0M0) who underwent preoperative MRI between December 2016 and December 2018. Based on the number of positive axillary lymph nodes (LNs) determined by postoperative pathology, the patients were divided into high nodal burden (HNB; ≥3 positive LNs) and non-HNB (<3 positive LNs) groups. Univariable and multivariable logistic regression analyses were performed to identify independent risk factors associated with ANB. Predictive efficacy was evaluated using the receiver operating characteristic (ROC) curve and area under the curve (AUC). Univariable and multivariable Cox proportional hazards regression analyses were performed to determine preoperative features associated with DFS.We included 47 and 250 patients in the HNB and non-HNB groups, respectively. Multivariable logistic regression analysis revealed that multifocality/multicentricity (adjusted odds ratio [OR] = 3.905, 95% confidence interval [CI]: 1.685-9.051, P = 0.001) and peritumoral edema (adjusted OR = 3.734, 95% CI: 1.644-8.479, P = 0.002) were independent risk factors for HNB. Combined peritumoral edema and multifocality/multicentricity achieved an AUC of 0.760 (95% CI: 0.707-0.807) for predicting HNB, with a sensitivity and specificity of 83.0% and 63.2%, respectively. During the median follow-up period of 45 months (range, 5-61 months), 26 cases (8.75%) of breast cancer recurrence were observed. Multivariable Cox proportional hazards regression analysis indicated that younger age (adjusted hazard ratio [HR] = 3.166, 95% CI: 1.200-8.352, P = 0.021), larger tumor size (adjusted HR = 4.370, 95% CI: 1.671-11.428, P = 0.002), and multifocality/multicentricity (adjusted HR = 5.059, 95% CI: 2.166-11.818, P < 0.001) were independently associated with DFS.Preoperative breast MRI features may be associated with ANB and DFS in patients with early-stage breast cancer.Copyright © 2024 The Korean Society of Radiology.