长非编码RNA (lncRNA) 在细胞中的各种表观遗传和转录后事件中发挥关键作用，从而显着影响细胞过程，包括基因表达、发育和癌症等疾病。核受体 (NR) 是配体调节转录因子家族，通常调节参与广泛细胞过程、免疫反应和包括癌症在内的许多疾病的基因转录。由于它们作为基因表达调节剂的许多重叠作用，lncRNA 和 NR 介导的信号传递路径经常相互交叉。人们越来越认识到这些 lncRNA-NR 串扰在许多细胞过程和癌症等疾病中发挥着重要作用。在这里，我们回顾了lncRNA和NR，特别是生长因子调节受体，如雄激素受体（AR），在各种类型的癌症中的各自作用，以及lncRNA和NR之间的相互作用如何参与癌症进展和转移。我们讨论了表征 lncRNA-NR 关联所涉及的挑战以及如何克服这些挑战。进一步了解 lncRNA-NR 关联机制对于实现其作为癌症生物学中的预后特征、诊断生物标志物和治疗靶点的潜力至关重要。

Long non-coding RNAs (lncRNAs) play key roles in various epigenetic and post-transcriptional events in the cell, thereby significantly influencing cellular processes including gene expression, development and diseases such as cancer. Nuclear receptors (NRs) are a family of ligand-regulated transcription factors that typically regulate transcription of genes involved in a broad spectrum of cellular processes, immune responses and in many diseases including cancer. Owing to their many overlapping roles as modulators of gene expression, the paths traversed by lncRNA and NR-mediated signaling often cross each other; these lncRNA-NR cross-talks are being increasingly recognized as important players in many cellular processes and diseases such as cancer. Here, we review the individual roles of lncRNAs and NRs, especially growth factor modulated receptors such as androgen receptors (ARs), in various types of cancers and how the cross-talks between lncRNAs and NRs are involved in cancer progression and metastasis. We discuss the challenges involved in characterizing lncRNA-NR associations and how to overcome them. Furthering our understanding of the mechanisms of lncRNA-NR associations is crucial to realizing their potential as prognostic features, diagnostic biomarkers and therapeutic targets in cancer biology.