与阑尾神经内分泌肿瘤患者淋巴结疾病相关的病理特征。
Pathological Features Associated with Lymph Node Disease in Patients with Appendiceal Neuroendocrine Tumors.
发表日期：2024 Aug 22
作者：
Salvador Rodriguez Franco, Sumaya Abdul Ghaffar, Ying Jin, Reed Weiss, Mona Hamermesh, Andrii Khomiak, Toshitaka Sugawara, Oskar Franklin, Alexis D Leal, Christopher H Lieu, Richard D Schulick, Marco Del Chiaro, Steven Ahrendt, Martin D McCarter, Ana L Gleisner
来源：
Cancers
摘要：
本研究旨在评估肿瘤大小之外的病理特征在阑尾神经内分泌肿瘤淋巴结转移风险中的作用。分析国家癌症数据库数据发现，5353例中，18.8%有淋巴结转移。专注于小于 2 厘米的肿瘤（治疗策略中备受争议的主题），我们确定淋巴血管侵犯是淋巴结疾病最强的预测因素之一。有趣的是，分期系统中当前的一个因素，延伸到浆膜下及以外的区域并不是一个强有力的预测因素。这些发现表明，在使用当前分期系统选择治疗方法时，需要仔细解释病理特征。
This study aimed to evaluate the role of pathological features beyond tumor size in the risk of lymph node metastasis in appendiceal neuroendocrine tumors. Analyzing data from the national cancer database, we found that among 5353 cases, 18.8% had lymph node metastasis. Focusing on tumors smaller than 2 cm, a subject of considerable debate in treatment strategies, we identified lymphovascular invasion as one of the strongest predictors of lymph node disease. Interestingly, extension into the subserosa and beyond, a current factor in the staging system, was not a strong predictor. These findings suggest that careful interpretation of pathological features is needed when selecting therapeutic approaches using current staging systems.